Evidence map›Paper›PMID 37692606›Full record

ArticleCureus2023

The Effect of Fluid Pre-loading on Vital Signs and Hemodynamic Parameters in a Porcine Model of Lipopolysaccharide-Induced Endotoxemia.

Zachary R Bergman, Roy K Kiberenge, Richard Bianco, Gregory Beilman, Colleen M Brophy, Kyle M Hocking, Bret D Alvis, Eric S Wise

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zachary R BergmanSurgery, University of Minnesota School of Medicine, Minneapolis, USA.
Roy K KiberengeCritical Care, Allina Health, Minneapolis, USA.
Richard BiancoSurgery, University of Minnesota School of Medicine, Minneapolis, USA.
Gregory BeilmanSurgery, University of Minnesota School of Medicine, Minneapolis, USA.
Colleen M BrophySurgery, Vanderbilt University Medical Center, Nashville, USA.
Kyle M HockingSurgery and Biomedical Engineering, Vanderbilt University Medical Center, Nashville, USA.
Bret D AlvisAnesthesiology and Biomedical Engineering, Vanderbilt University Medical Center, Nashville, USA.
Eric S WiseSurgery, University of Minnesota School of Medicine, Minneapolis, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Animal models of distributive hypotension and resuscitation allow the assessment of hemodynamic monitoring modalities and resuscitation strategies. The fluid-first paradigm for resuscitation is currently being challenged with clinical trials. In this investigation, venous return and perfusion are assessed, and full hemodynamics are characterized, in a porcine model of endotoxemic hypotension with and without fluid pre-loading. Methods Two groups of six pigs had the induction of standardized endotoxemic hypotension ("critical hypotension"). Group 1 underwent four 10 cc/kg crystalloid boluses, and Group 2 was not fluid pre-resuscitated. Both groups underwent progressive norepinephrine (NE) up-titration to 0.25 mcg/kg/minute over 30 minutes. Vital signs, central parameters, and laboratory values were obtained at baseline, "critical hypotension," after each bolus and during NE administration. Results Endotoxemia decreased the systemic vascular resistance (SVR) in Group 1 (1031±106 dyn/s/cm

Indexed as

endotoxemiahemodynamicsnorepinephrinesepsisvasoplegiavasopressor

Identifiers

PMID37692606
PMCPMC10483090

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.