Evidence map›Paper›PMID 37692372›Full record

ArticleEnvironmental research, health : ERH2023

Human milk EV-miRNAs: a novel biomarker for air pollution exposure during pregnancy.

Elizabeth A Holzhausen, Allison Kupsco, Bridget N Chalifour, William B Patterson, Kelsey A Schmidt, Pari Mokhtari, Fredrick Lurmann, Andrea A Baccarelli, Michael I Goran, Tanya L Alderete

Open access · diamondAbstract read
In one paragraph

Article in Environmental research, health : ERH, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Prenatal Nitrogen Oxide (NOEnvironmental science & technology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Elizabeth A HolzhausenDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States of America.ORCID https://orcid.org/0000-0002-1773-0099
Allison KupscoDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, United States of America.
Bridget N ChalifourDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States of America.ORCID https://orcid.org/0000-0001-8275-2457
William B PattersonDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States of America.ORCID https://orcid.org/0000-0001-8355-0857
Kelsey A SchmidtDepartment of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States of America.
Pari MokhtariDepartment of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States of America.
Fredrick LurmannSonoma Technology Inc., Petaluma, CA, United States of America.
Andrea A BaccarelliDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, United States of America.
Michael I GoranDepartment of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States of America.
Tanya L AldereteDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States of America.ORCID https://orcid.org/0000-0002-7751-9543
University of Colorado Boulder · USChildren's Hospital of Los Angeles · USColumbia University · USSonoma Technology (United States) · US

Funding

Southern California Center for Chronic Health Disparities in Latino Children and Families.P50MD017344 · NIMHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI BOUTELLE, KERRI N · 2021 to 2025
$27.8M
Impact of Sugars and Human Milk Oligosaccharides on Infant Microbiome and ObesityR01DK110793 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GORAN, MICHAEL ISAAC, PETERSON, BRADLEY S · 2017 to 2024
$6.0M
Near-Roadway and Ambient Air Pollution Exposure and the Gut Microbiome: Implications for Obesity and Insulin Resistance in AdolescenceR00ES027853 · NIEHS · UNIVERSITY OF COLORADO · PI ALDERETE, TANYA LYNN · 2018 to 2020
$721k
Exposure to Ambient Air Pollutants, Circulating microRNAs, and Hepatic Fat Fraction Among Young AdultsF31DK134198 · NIDDK · UNIVERSITY OF COLORADO · PI PATTERSON, WILLIAM BROOKS · 2022 to 2023
$80k
NIDDK NIH HHS F31 DK134198NIDDK NIH HHS R01 DK110793NIEHS NIH HHS R00 ES027853NIMHD NIH HHS P50 MD017344
6 · The paper itself

Abstract

Exposure to ambient and near-roadway air pollution during pregnancy has been linked with several adverse health outcomes for pregnant women and their babies. Emerging research indicates that microRNA (miRNA) expression can be altered by exposure to air pollutants in a variety of tissues. Additionally, miRNAs from breast tissue and circulating miRNAs have previously been proposed as a biomarker for breast cancer diagnosis and prognosis. Therefore, this study sought to evaluate the associations between pregnancy exposures to ambient (PM

Indexed as

air pollutionbreast milkEV-miRNAshuman milknear-roadway air pollutionparticulate matter

Identifiers

PMID37692372
PMCPMC10486183
OpenAlexW4381617723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.