Evidence map›Paper›PMID 37692287›Full record

ArticleiScience2023

mRNA splicing is modulated by intronic microRNAs.

Luba Farberov, Daphna Weissglas-Volkov, Guy Shapira, Yazeed Zoabi, Chen Schiff, Barbara Kloeckener-Gruissem, John Neidhardt, Noam Shomron

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 4 countries.

Luba FarberovFaculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Daphna Weissglas-VolkovFaculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Guy ShapiraFaculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Yazeed ZoabiFaculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Chen SchiffFaculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Barbara Kloeckener-GruissemInstitute of Medical Molecular Genetics, University of Zurich, Zurich, Switzerland.
John NeidhardtHuman Genetics, Faculty of Medicine and Health Sciences, University of Oldenburg, Germany.
Noam ShomronFaculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Tel Aviv University · ILCarl von Ossietzky Universität Oldenburg · DEUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Splicing of transcripts is catalyzed by the spliceosome, a mega-complex consisting of hundreds of proteins and five snRNAs, which employs direct interactions. When U1 snRNA forms high-affinity binding, namely more than eight base pairs, with the 5'SS, the result is usually a suppressing effect on the splicing activity. This likely occurs due to the inefficient unwinding of U1/5'SS base-pairing or other regulatory obstructions. Here, we show

Indexed as

Cell biologyFunctional aspects of cell biologyMolecular biology

Identifiers

PMID37692287
PMCPMC10492213
OpenAlexW4386226959

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.