ArticleFrontiers in psychology2023
Resting-state functional connectivity is modulated by cognitive reserve in early Parkinson's disease.
Article in Frontiers in psychology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Role of α-Synuclein in the Prefrontal Cortex: From Physiological Synaptic Modulation to Synaptic Failure in Parkinson's Disease.Biomedicines · 2026Review
- Iron accumulation in the substantia nigra is linked to functional network connectivity alterations in early-stage Parkinson's Disease: an exploratory study.NPJ Parkinson's disease · 2026Article
- Shared white matter connectome-based correlates of self-reproach, response failure, spatial planning, and resilience in patients with subthreshold depression: a graph theory approach.Scientific reports · 2026Article
- Article
- Brain Tumors, AI and Psychiatry: Predicting Tumor-Associated Psychiatric Syndromes with Machine Learning and Biomarkers.International journal of molecular sciences · 2025Review
- Multimodal magnetic resonance imaging studies on non-motor symptoms of Parkinson's disease.IBRO neuroscience reports · 2025Article
- Segregation and integration of resting-state brain networks in a longitudinal long COVID cohort.iScience · 2025Article
- Linking cognitive reserve to neuropsychological outcomes and resting-state frequency bands in healthy aging.Frontiers in aging neuroscience · 2025Article
- The Contribution of Cognitive Control Networks in Word Selection Processing in Parkinson's Disease: Novel Insights from a Functional Connectivity Study.Brain sciences · 2024Article
- Exploring cognitive reserve's influence: unveiling the dynamics of digital telerehabilitation in Parkinson's Disease Resilience.NPJ digital medicine · 2024Article
- Cognitive Reserve proxies can modulate motor and non-motor basal ganglia circuits in early Parkinson's Disease.Brain imaging and behavior · 2024Article
- Editorial: Insights in neurocognitive aging and behavior: 2022.Frontiers in aging neuroscience · 2024Article
- Pathobiology of Cognitive Impairment in Parkinson Disease: Challenges and Outlooks.International journal of molecular sciences · 2023Review
- Relationship between lifestyle proxies of cognitive reserve and cortical regions in older adults.Frontiers in psychology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Fronto-striatal disconnection is thought to be at the basis of dysexecutive symptoms in patients with Parkinson's disease (PD). Multiple reserve-related processes may offer resilience against functional decline. Among these, cognitive reserve (CR) refers to the adaptability of cognitive processes. Objective: To test the hypothesis that functional connectivity of pathways associated with executive dysfunction in PD is modulated by CR. Methods: Twenty-six PD patients and 24 controls underwent resting-state functional magnetic resonance imaging. Functional connectivity was explored with independent component analysis and seed-based approaches. The following networks were selected from the outcome of the independent component analysis: default-mode (DMN), left and right fronto-parietal (l/rFPN), salience (SalN), sensorimotor (SMN), and occipital visual (OVN). Seed regions were selected in the substantia nigra and in the dorsolateral and ventromedial prefrontal cortex for the assessment of seed-based functional connectivity maps. Educational and occupational attainments were used as CR proxies. Results: Compared with their counterparts with high CR, PD individuals with low CR had reduced posterior DMN functional connectivity in the anterior cingulate and basal ganglia, and bilaterally reduced connectivity in fronto-parietal regions within the networks defined by the dorsolateral and ventrolateral prefrontal seeds. Hyper-connectivity was detected within medial prefrontal regions when comparing low-CR PD with low-CR controls. Conclusion: CR may exert a modulatory effect on functional connectivity in basal ganglia and executive-attentional fronto-parietal networks. In PD patients with low CR, attentional control networks seem to be downregulated, whereas higher recruitment of medial frontal regions suggests compensation via an upregulation mechanism. This upregulation might contribute to maintaining efficient cognitive functioning when posterior cortical function is progressively reduced.
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