Evidence map›Paper›PMID 37691754›Full record

ArticleGastroenterology research2023

Xheni Deda, Khaled Elfert, Mustafa Gandhi, Alexander Malik, Esraa Elromisy, Nehemias Guevara, Suresh Nayudu, Matthew Bechtold

Abstract read
In one paragraph

Article in Gastroenterology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Clinical Characteristics and Risk Factors ofJournal of clinical medicine · 2026
    Article
  2. Article
  3. Le infezioni in medicina · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xheni DedaDivision of Gastroenterology and Hepatology, University of Missouri, Columbia, MO, USA.
Khaled ElfertDepartment of Medicine, SBH Health System, New York, NY, USA.
Mustafa GandhiDivision of Gastroenterology and Hepatology, University of Missouri, Columbia, MO, USA.
Alexander MalikDepartment of Medicine, Summa Health System, Akron, OH, USA.
Esraa ElromisyDepartment of Medicine, Tanta University Faculty of Medicine, Tanta, Egypt.
Nehemias GuevaraDepartment of Medicine, SBH Health System, New York, NY, USA.
Suresh NayuduDepartment of Medicine, SBH Health System, New York, NY, USA.
Matthew BechtoldDivision of Gastroenterology and Hepatology, University of Missouri, Columbia, MO, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: The NIS database was searched for adult patients hospitalized with a primary diagnosis of COVID-19 infection in 2020. Patients with a secondary diagnosis of CDI were identified and separated into two groups based on CDI status. Baseline characteristics, Charlson Comorbidity Index (CCI), and outcomes were compared between the two groups using Chi-square and Results: A total of 1,045,125 COVID-19 hospitalizations were included, of which 4,920 had a secondary diagnosis of CDI. Patients with CDI and COVID-19 were older (mean age 69.9 vs. 64.2 years; P < 0.001), more likely to be female (54.1% vs. 47.1%; P < 0.001) and white (60% vs. 52.4%; P < 0.001). The CDI and COVID-19 group had a longer length of stay (14.1 vs. 7.42 days; P < 0.001), higher total hospital costs ($42,336 vs. $18,974; P < 0.001), and higher inpatient mortality (21.6% vs. 11%; P < 0.001) compared to the COVID-19 group without CDI. Patients in the CDI and COVID-19 group had a higher CCI score (51.7% with a score of 3 or more vs. 27.7%; P < 0.001), indicating a higher comorbidity burden. Multivariate logistic regression analysis revealed CDI was independently associated with increased mortality (odds ratio (OR) 1.37; P = 0.001) and showed that the female gender and several pre-existing comorbidities were associated with a higher likelihood of CDI. Conclusion: CDI is independently associated with increased mortality in patients admitted with COVID-19 infection. Female gender and several pre-existing comorbidities are independent predictors of CDI in COVID-19 patients.

Indexed as

Clostridioides difficile infectionColitisCOVID-19National Inpatient Sample

Identifiers

PMID37691754
PMCPMC10482604

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.