Evidence map›Paper›PMID 37691640›Full record

ReviewJournal of orthopaedic translation2023

Biomaterial-based scaffolds in promotion of cartilage regeneration: Recent advances and emerging applications.

Jingqi Liang, Peilong Liu, Xinquan Yang, Liang Liu, Yan Zhang, Qiong Wang, Hongmou Zhao

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of orthopaedic translation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
16.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jingqi LiangDepartment of Foot and Ankle Surgery, Honghui Hospital of Xi'an Jiaotong University, Xi'an, China.
Peilong LiuDepartment of Foot and Ankle Surgery, Honghui Hospital of Xi'an Jiaotong University, Xi'an, China.
Xinquan YangDepartment of Foot and Ankle Surgery, Honghui Hospital of Xi'an Jiaotong University, Xi'an, China.
Liang LiuDepartment of Foot and Ankle Surgery, Honghui Hospital of Xi'an Jiaotong University, Xi'an, China.
Yan ZhangDepartment of Foot and Ankle Surgery, Honghui Hospital of Xi'an Jiaotong University, Xi'an, China.
Qiong WangDepartment of Foot and Ankle Surgery, Honghui Hospital of Xi'an Jiaotong University, Xi'an, China.
Hongmou ZhaoDepartment of Foot and Ankle Surgery, Honghui Hospital of Xi'an Jiaotong University, Xi'an, China.
Xi'an Honghui Hospital · CNXi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) poses a significant burden for countless individuals, inflicting relentless pain and impairing their quality of life. Although traditional treatments for OA focus on pain management and surgical interventions, they often fall short of addressing the underlying cause of the disease. Fortunately, emerging biomaterial-based scaffolds offer hope for OA therapy, providing immense promise for cartilage regeneration in OA. These innovative scaffolds are ingeniously designed to provide support and mimic the intricate structure of the natural extracellular matrix, thus stimulating the regeneration of damaged cartilage. In this comprehensive review, we summarize and discuss current landscape of biomaterial-based scaffolds for cartilage regeneration in OA. Furthermore, we delve into the diverse range of biomaterials employed in their construction and explore the cutting-edge techniques utilized in their fabrication. By examining both preclinical and clinical studies, we aim to illuminate the remarkable versatility and untapped potential of biomaterial-based scaffolds in the context of OA. Thetranslational potential of this article: By thoroughly examining the current state of research and clinical studies, this review provides valuable insights that bridge the gap between scientific knowledge and practical application. This knowledge is crucial for clinicians and researchers who strive to develop innovative treatments that go beyond symptom management and directly target the underlying cause of OA. Through the comprehensive analysis and multidisciplinary approach, the review paves the way for the translation of scientific knowledge into practical applications, ultimately improving the lives of individuals suffering from OA and shaping the future of orthopedic medicine.

Indexed as

BiomaterialsCartilageOsteoarthritisRANKLRegenerationScaffolds

Identifiers

PMID37691640
PMCPMC10485599
OpenAlexW4386427403

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.