Evidence map›Paper›PMID 37691515›Full record

ArticleThe EMBO journal2023

Got PIDD1? Natural killer cells clear polyploid cells to ensure a balanced genome.

Alexandra N Brown-Suedel, Lisa Bouchier-Hayes

Open access · greenAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. The concealed side of caspases: beyond a killer of cells.Cellular and molecular life sciences : CMLS · 2024
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alexandra N Brown-SuedelDepartment of Pediatrics, Division of Hematology-Oncology, Baylor College of Medicine, Houston, TX, USA.
Lisa Bouchier-HayesDepartment of Pediatrics, Division of Hematology-Oncology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-3886-5977
Baylor College of Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Removal of polyploid cells is essential to preventing cancer and restricting tumor growth. A new study published in The EMBO Journal shows assembly of the NEMO-PIDDosome on extra centrioles. Activation of this protein complex leads to NF-κB activation that, in turn, induces NK cell-mediated cell clearance.

Indexed as

NF-kappa BSignal TransductionDeath Domain Receptor Signaling Adaptor ProteinsGene Expression RegulationHumansI-kappa B KinaseKiller Cells, NaturalPolyploidyDeath Domain Receptor Signaling Adaptor ProteinsI-kappa B KinaseNF-kappa BPIDD1 protein, humanPidd1 protein, mouse

Identifiers

PMID37691515
PMCPMC10577535
OpenAlexW4386592616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.