Evidence map›Paper›PMID 37691493›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2023

Do the current MS clinical course descriptors need to change and if so how? A survey of the MS community.

Alan J Thompson, Marcello Moccia, Maria Pia Amato, Peter A Calabresi, Marcia Finlayson, Annie Hawton, Fred D Lublin, Ruth Ann Marrie, Xavier Montalban, Michael Panzara and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. The refined Pathways to Cures Research Roadmap for multiple sclerosis cures.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 5 countries.

Alan J ThompsonQueen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, NIHR University College London Hospitals Biomedical Research Centre, Faculty of Brain Sciences, University College London, London, UK.ORCID 0000-0002-4333-8496
Marcello MocciaDepartment of Molecular Biology and Molecular Biotechnology, Federico II University of Naples, Naples, Italy Multiple Sclerosis Unit, Policlinico Federico II University Hospital, Naples, Italy.ORCID 0000-0003-2613-3090
Maria Pia AmatoDepartment NEUROFARBA, Section of Neurosciences, University of Florence, Florence, Italy IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.ORCID 0000-0003-3325-3760
Peter A CalabresiDepartment of Neurology and The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-7776-6472
Marcia FinlaysonSchool of Rehabilitation Therapy, Queens University, Kingston, ON, Canada.ORCID 0000-0002-1774-4810
Annie HawtonUniversity of Exeter Medical School, University of Exeter, Exeter, UK.ORCID 0000-0002-1336-5899
Fred D LublinDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ruth Ann MarrieDepartments of Medicine & Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.ORCID 0000-0002-1855-5595
Xavier MontalbanMultiple Sclerosis Centre of Catalonia and Department of Neurology-Neuroimmunology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
Michael PanzaraNeurvati Neurosciences, New York, NY, USA.
Maria Pia SormaniDepartment of Health Sciences, University of Genoa, Genoa, Italy IRCCS Ospedale Policlinico San Martino, Genoa, Italy.ORCID 0000-0001-6892-104X
Jon StrumRealTalk MS, Long Beach, CA, USA.
Barbara G VickreyDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Timothy CoetzeeNational Multiple Sclerosis Society, 733 Third Avenue, New York, NY 10017, USA.ORCID 0000-0002-3031-7549
Icahn School of Medicine at Mount Sinai · USDon Carlo Gnocchi Foundation · ITFederico II University Hospital · ITJohns Hopkins University · USNational Multiple Sclerosis Society · USOspedale Policlinico San Martino · ITQueen's University · CAUCL Biomedical Research Centre · GBUniversitat Autònoma de Barcelona · ESUniversity of Exeter · GBUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe current clinical course descriptors of multiple sclerosis (MS) include a combination of clinical and magnetic resonance imaging (MRI) features. Recently there has been a growing call to base these descriptors more firmly on biological mechanisms. We investigated the implications of proposing a new mechanism-driven framework for describing MS.

methodsIn a web-based survey, multiple stakeholders rated the need to change current MS clinical course descriptors, the definitions of disease course and their value in clinical practice and related topics.

resultsWe received 502 responses across 49 countries. In all, 77% of the survey respondents supported changing the current MS clinical course descriptors. They preferred a framework that informs treatment decisions, aids the design and conduct of clinical trials, allows patients to understand their disease, and links disease mechanisms and clinical expression of disease. Clinical validation before dissemination and ease of communication to patients were rated as the most important aspects to consider when developing any new framework for describing MS.

conclusionA majority of MS stakeholders agreed that the current MS clinical course descriptors need to change. Any change process will need to engage a wide range of affected stakeholders and be guided by foundational principles.

Indexed as

Multiple SclerosisMultiple Sclerosis, Relapsing-RemittingDisease ProgressionHumansMagnetic Resonance ImagingSurveys and Questionnairesclinical courseMultiple sclerosisprogressionprogressive multiple sclerosisrelapsesrelapsing multiple sclerosis

Identifiers

PMID37691493
PMCPMC10580678
OpenAlexW4386591827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.