Evidence map›Paper›PMID 37691404›Full record

ArticlePharmaceutical biology2023

Evaluation of topical methylene blue nanoemulsion for wound healing in diabetic mice.

Yu Gao, Zhounan Jiang, Bin Xu, Ran Mo, Shiyan Li, Yanan Jiang, Demei Zhao, Wangbin Cao, Bin Chen, Meng Tian and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Yu GaoNanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
Zhounan JiangThe Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Bin XuHubei Xiangyang Central Hospital, Xiangyang, China.
Ran MoDepartment of Burns and Plastic Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Shiyan LiDepartment of Burns and Plastic Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Yanan JiangDepartment of Burns and Plastic Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Demei ZhaoDepartment of Burns and Plastic Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Wangbin CaoNanjing Hospital of Traditional Chinese Medicine, Nanjing, China.
Bin ChenInstitute of Plant Resources and Chemistry, Nanjing Research Institute for Comprehensive Utilization of Wild Plants, Nanjing, China.
Meng TianDepartment of Plastic Surgery, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Qian TanNanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
Nanjing Drum Tower Hospital · CNNanjing Medical University · CNNanjing Traditional Chinese Medicine Hospital · CNSecond Affiliated Hospital of Zhejiang University · CNTongji University · CNXiangyang Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextDiabetic wounds (DW) are a complication of diabetes and slow wound healing is the main manifestation. Methylene blue (MB) has been shown to exhibit therapeutic effects on diabetes-related diseases.

objectiveTo investigate the mechanisms of action of MB-nanoemulsion (NE) in the treatment of DW. MATERIALS AND

methodsThe concentration of MB-NE used in the

resultsIn diabetic mice, the MB-NE accelerated DW healing ( DISCUSSION AND

conclusionThis study provides a foundation for the application of MB-NE in the treatment of DW.

Indexed as

Diabetes Mellitus, ExperimentalAnimalsHumansHuman Umbilical Vein Endothelial CellsMethylene BlueMiceNF-E2-Related Factor 2Reactive Oxygen SpeciesVascular Endothelial Growth Factor AMethylene BlueNF-E2-Related Factor 2Reactive Oxygen SpeciesVascular Endothelial Growth Factor ADiabetic woundinhibit apoptosisNrf2

Identifiers

PMID37691404
PMCPMC10496548
OpenAlexW4386593171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.