Evidence map›Paper›PMID 37691341›Full record

Trial reportEuropean journal of neurology2024

Home-based exergaming to treat gait and balance disorders in patients with Parkinson's disease: A phase II randomized controlled trial.

Dijana Nuic, Sjors van de Weijer, Saoussen Cherif, Anna Skrzatek, Eline Zeeboer, Claire Olivier, Jean-Christophe Corvol, Pierre Foulon, Jénica Z Pastor, Gregoire Mercier and 4 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled TrialClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03560089 (Serious Games Rehabilitation Programme to Treat Gant and Balance Disorders in Patients With Parkinson's Disease), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03560089 nacompletednot on this map

Serious Games Rehabilitation Programme to Treat Gant and Balance Disorders in Patients With Parkinson's Disease

TypeinterventionalSponsorInstitut National de la Santé Et de la Recherche Médicale, FranceRan2018 to 2021Enrolled25ConditionsParkinson DiseaseArmsSerious game, Placebo serious game
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Combinations of physical and cognitive training for subcortical neurodegenerative diseases with physical, cognitive and behavioral symptoms: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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  17. Physical exercise-mediated neuroprotective mechanisms in Parkinson's disease, Alzheimer's disease, and epilepsy.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Dijana NuicParis Brain Institute, CNRS UMR 7225, INSERM 1127, Sorbonne University, Paris, France.
Sjors van de WeijerDonders Institute for Brain, Cognition, and Behavior and Department of Neurology, Center of Expertise for Parkinson and Movement, Radboud University Medical Center, Nijmegen, The Netherlands.
Saoussen CherifParis Brain Institute, CNRS UMR 7225, INSERM 1127, Sorbonne University, Paris, France.
Anna SkrzatekParis Brain Institute, CNRS UMR 7225, INSERM 1127, Sorbonne University, Paris, France.
Eline ZeeboerDonders Institute for Brain, Cognition, and Behavior and Department of Neurology, Center of Expertise for Parkinson and Movement, Radboud University Medical Center, Nijmegen, The Netherlands.
Claire OlivierParis Brain Institute, CNRS UMR 7225, INSERM 1127, Sorbonne University, Paris, France.
Jean-Christophe CorvolParis Brain Institute, CNRS UMR 7225, INSERM 1127, Sorbonne University, Paris, France.
Pierre FoulonLabCom Brain e-Novation, Paris Brain Institute, Paris, France.
Jénica Z PastorBiostatistics Department, CHU de Montpellier, Montpellier, France.
Gregoire MercierBiostatistics Department, CHU de Montpellier, Montpellier, France.
Brian LauParis Brain Institute, CNRS UMR 7225, INSERM 1127, Sorbonne University, Paris, France.
Bastiaan R BloemDonders Institute for Brain, Cognition, and Behavior and Department of Neurology, Center of Expertise for Parkinson and Movement, Radboud University Medical Center, Nijmegen, The Netherlands.
Nienke M De VriesDonders Institute for Brain, Cognition, and Behavior and Department of Neurology, Center of Expertise for Parkinson and Movement, Radboud University Medical Center, Nijmegen, The Netherlands.
Marie-Laure WelterParis Brain Institute, CNRS UMR 7225, INSERM 1127, Sorbonne University, Paris, France.ORCID 0000-0003-1423-5620
Centre National de la Recherche Scientifique · FRRadboud University Nijmegen · NLInserm · FRUniversité de Montpellier · FR

Funding

Agence Nationale de la RechercheEurostars programmeFrance Parkinson Foundation
6 · The paper itself

Abstract

backgroundExergaming has been proposed to improve gait and balance disorders in Parkinson's disease (PD) patients. We aimed to assess the efficacy of a home-based, tailored, exergaming training system designed for PD patients with dopa-resistant gait and/or balance disorders in a controlled randomized trial.

methodsWe recruited PD patients with dopa-resistant gait and/or balance disorders. Patients were randomly assigned (1:1 ratio) to receive 18 training sessions at home by playing a tailored exergame with full-body movements using a motion capture system (Active group), or by playing the same game with the computer's keyboard (Control group). The primary endpoint was the between-group difference in the Stand-Walk-Sit Test (SWST) duration change after training. Secondary outcomes included parkinsonian clinical scales, gait recordings, and safety.

resultsFifty PD patients were enrolled and randomized. After training, no significant difference in SWST change was found between groups (mean change SWST duration [SD] -3.71 [18.06] s after Active versus -0.71 [3.41] s after Control training, p = 0.61). Some 32% of patients in the Active and 8% in the Control group were considered responders to the training program (e.g., SWST duration change ≥2 s, p = 0.03). The clinical severity of gait and balance disorders also significantly decreased after Active training, with a between-group difference in favor of the Active training (p = 0.0082). Home-based training induced no serious adverse events.

conclusionsHome-based training using a tailored exergame can be performed safely by PD patients and could improve gait and balance disorders. Future research is needed to investigate the potential of exergaming.

Indexed as

Parkinson DiseaseVideo GamesDihydroxyphenylalanineExercise TherapyExergamingGaitHumansPostural BalanceDihydroxyphenylalanineexergamingfallsgait disordersParkinson's diseaserehabilitation

Identifiers

PMID37691341
PMCPMC11236010
OpenAlexW4386592179

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.