Evidence map›Paper›PMID 37691330›Full record

ArticleJournal of movement disorders2024

Caregiver Burden of Patients With Huntington's Disease in South Korea.

Chan Young Lee, Chaewon Shin, Yun Su Hwang, Eungseok Oh, Manho Kim, Hyun Sook Kim, Sun Ju Chung, Young Hee Sung, Won Tae Yoon, Jin Whan Cho and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of movement disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Chan Young LeeDepartment of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea.
Chaewon ShinDepartment of Neurology, Chungnam National University Sejong Hospital, Chungnam National University College of Medicine, Sejong, Korea.
Yun Su HwangDepartment of Neurology, Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju, Korea.
Eungseok OhDepartment of Neurology, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Korea.
Manho KimDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Hyun Sook KimDepartment of Neurology, Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.
Sun Ju ChungDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Young Hee SungDepartment of Neurology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
Won Tae YoonDepartment of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Jin Whan ChoDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Jae-Hyeok LeeDepartment of Neurology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
Han-Joon KimDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Hee Jin ChangDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Beomseok JeonDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Kyung Ah WooDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Seong-Beom KohDepartment of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Kyum-Yil KwonDepartment of Neurology, Soonchunhyang University Seoul Hospital, Seoul, Korea.
Jangsup MoonDepartment of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Young Eun KimDepartment of Neurology, Hallym University Sacred Heart Hospital, Anyang, Korea.
Jee-Young LeeDepartment of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.

Funding

Seoul National University 04-2022-0014
6 · The paper itself

Abstract

objectiveThis is the first prospective cohort study of Huntington's disease (HD) in Korea. This study aimed to investigate the caregiver burden in relation to the characteristics of patients and caregivers.

methodsFrom August 2020 to February 2022, we enrolled patients with HD from 13 university hospitals in Korea. We used the 12-item Zarit Burden Interview (ZBI-12) to evaluate the caregiver burden. We evaluated the clinical associations of the ZBI-12 scores by linear regression analysis and investigated the differences between the low- and high-burden groups.

resultsSixty-five patients with HD and 45 caregivers were enrolled in this cohort study. The average age at onset of motor symptoms was 49.3 ± 12.3 years, with an average cytosine-adenine-guanine (CAG)n of 42.9 ± 4.0 (38-65). The median ZBI-12 score among our caregivers was 17.6 ± 14.2. A higher caregiver burden was associated with a more severe Shoulson-Fahn stage (p = 0.038) of the patients. A higher ZBI-12 score was also associated with lower independence scale (B = -0.154, p = 0.006) and functional capacity (B = -1.082, p = 0.002) scores of patients. The caregiving duration was longer in the high- than in the low-burden group. Caregivers' demographics, blood relation, and marital and social status did not affect the burden significantly.

conclusionHD patients' neurological status exerts an enormous impact on the caregiver burden regardless of the demographic or social status of the caregiver. This study emphasizes the need to establish an optimal support system for families dealing with HD in Korea. A future longitudinal analysis could help us understand how disease progression aggravates the caregiver burden throughout the entire disease course.

Indexed as

Caregiver burdenFunctional capacityHuntington’s diseaseIndependencyProspective cohort

Identifiers

PMID37691330
PMCPMC10846961

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.