ArticleJournal of the National Cancer Institute2024
Ambient fine particulate matter and breast cancer incidence in a large prospective US cohort.
Article in Journal of the National Cancer Institute, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Industrial Pollution and Health in Louisiana: A Systematic Review of Quantitative and Qualitative Studies.Current environmental health reports · 2026Pooled it
- Impact of Pollution on Cancer: A Systematic Review and Meta-Analysis with Focus on Air Pollution.International journal of environmental research and public health · 2026Pooled it
- Associations of Outdoor Air Pollution With Incidence of Cancers Other Than Lung Cancer in a Large US Prospective Cohort.International journal of cancer · 2026Article
- Environmental factors shaping cancer outcomes in Alabama: A scoping review.Journal of cancer survivorship : research and practice · 2026Review
- Long-term outdoor air pollution and risk of ovarian and endometrial cancers in a large prospective cohort.Journal of exposure science & environmental epidemiology · 2026Article
- Factors associated with the occurrence of breast nodules in perimenopausal women: A cross-sectional study in China.Medicine · 2026Article
- Industrial point source emissions and incident breast and lung cancers: two case-control studies.Cancer causes & control : CCC · 2026Article
- Long-term atmospheric exposure to particulate matter and breast cancer risk: findings from a nested case-control study in France.British journal of cancer · 2026Article
- Differential effects of neighborhood ambient PMInternational journal of health geographics · 2026Article
- Residential Proximity to NPL Superfund Sites and High Particulate Matter Exposure Is Associated with Increased Likelihood of Triple-Negative Breast Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Climate change, environmental exposures, and breast cancer: advancing climate-resilient oncology through sustainable development goal 13.Frontiers in public health · 2026Review
- Molecular mechanisms of air pollution-induced carcinogenesis and the emerging role of microplastics.Human genomics · 2025Review
- Air pollution and breast cancer incidence in a United States-wide prospective cohort study: Examining sensitive periods of exposure.Environment international · 2025Article
- Long-term exposure to PMThe Lancet. Planetary health · 2025Article
- Air Pollutants and Breast Cancer Risk: A Parallel Analysis of Five Large US Prospective Cohorts.American journal of public health · 2025Article
- Exposure to ambient air pollution during pregnancy and risk of early-onset breast cancer.Breast cancer research : BCR · 2025Article
- Ambient air pollution and mortality in older patients with breast cancer.Journal of the National Cancer Institute · 2025Article
- Wildland firefighter exposure and female cancer risk: currently available evidence.Annals of work exposures and health · 2025Article
- Residential proximity to national priorities list superfund sites is associated with increased likelihood of metastatic breast cancer presentation.Scientific reports · 2025Article
- Causal associations between air pollution and breast cancer risk and survival: a Mendelian randomization study.Discover oncology · 2025Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundFine particulate matter (PM2.5) has been inconsistently associated with breast cancer incidence, however, few studies have considered historic exposure when levels were higher.
methodsOutdoor residential PM2.5 concentrations were estimated using a nationwide spatiotemporal model for women in the National Institutes of Health-AARP Diet and Health Study, a prospective cohort located in 6 states (California, Florida, Louisiana, New Jersey, North Carolina, and Pennsylvania) and 2 metropolitan areas (Atlanta, GA, and Detroit, MI) and enrolled in 1995-1996 (n = 196 905). Annual average PM2.5 concentrations were estimated for a 5-year historical period 10 years prior to enrollment (1980-1984). We used Cox regression to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between a 10 µg/m3 increase in PM2.5 and breast cancer incidence overall and by estrogen receptor status and catchment area.
resultsWith follow-up of participants through 2017, a total of 15 870 breast cancer cases were identified. A 10 ug/m3 increase in PM2.5 was statistically significantly associated with overall breast cancer incidence (HR = 1.08, 95% CI = 1.02 to 1.13). The association was evident for estrogen receptor-positive (HR = 1.10, 95% CI = 1.04 to 1.17) but not estrogen receptor-negative tumors (HR = 0.97, 95% CI = 0.84 to 1.13; Pheterogeneity = .3). Overall breast cancer hazard ratios were more than 1 across the catchment areas, ranging from a hazard ratio of 1.26 (95% CI = 0.96 to 1.64) for North Carolina to a hazard ratio of 1.04 (95% CI = 0.68 to 1.57) for Louisiana (Pheterogeneity = .9).
conclusionsIn this large US cohort with historical air pollutant exposure estimates, PM2.5 was associated with risk of estrogen receptor-positive breast cancer. State-specific estimates were imprecise but suggest that future work should consider region-specific associations and the potential contribution of PM2.5 chemical constituency in modifying the observed association.
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