ArticleThyroid research2023
Impact of thyroid hormone treatment on maternal pregnancy outcomes in women with subclinical hypothyroidism without TPOAb: a retrospective cross-sectional study.
Article in Thyroid research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Comparison of severe maternal morbidity between pregnancy with subclinical hypothyroidism and overt hypothyroidism.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Exploring the determinants of thyroid disorders in high-altitude western Himalaya: a geospatial and epidemiological study.Journal of health, population, and nutrition · 2025Article
- Prevalence of Subclinical Hypothyroidism in Information Technology Professionals With High Screen Exposure.Cureus · 2025Article
- Effect of levothyroxine treatment on serum lipids and pregnancy outcomes in pregnant women with isolated hypothyroxinemia.Scientific reports · 2025Article
- Comparing Blood Pressure in Pregnant Women with Subclinical Hypothyroidism Using Levothyroxine to those with Euthyroid Status.Advanced biomedical research · 2025Article
- Subclinical Hypothyroidism and Gestational Hypertensive Disorders in a Cohort of Romanian Pregnant Women with Gestational Diabetes Mellitus: A Pilot Study.Biomedicines · 2024Article
- Maternal hypothyroidism and the risk of preeclampsia: a Danish national and regional study.Maternal health, neonatology and perinatology · 2024Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence on the impact of thyroid hormone treatment (LT4) on maternal pregnancy outcomes in women with subclinical hypothyroidism (SCH) without thyroid peroxidase antibodies (TPOAb) positivity is scarce.
methodsSingle centre, cross-sectional study in 1460 women screened for TSH, free T4 and TPOAb at median 13 (11-17) weeks of gestation during the period 2013-2014. Exclusion criteria were twin- and assisted reproduction pregnancies, TPO positivity, overt thyroid dysfunction, and treatment with LT4 before screening. The impact of LT4 on maternal pregnancy outcomes was investigated in a group of 53 women with SCH (TSH > 3.74 mIU/L) in which LT4 was initiated at median 13 (10-22) weeks (treated group). The control group included 18 women with SCH (TSH > 3.74 mIU/L). The prevalence of pregnancy complications in these two groups was compared with that in a euthyroid reference (REF) group of 1389 women (TSH ≤ 3.74 mIU/L).
resultsThe prevalence of pre-eclampsia and gestational diabetes (GDM) was higher in the control group vs the REF group (16.7% vs 5.0% and 27.8% vs 18.9%; p = 0.017 and p = 0.016, respectively), but comparable in the treated group vs the REF group (7.6% vs 5.0% and 22.6% vs 18.9%; p = 0.918 and 0.676, respectively). The prevalence of iron-deficiency anaemia was lower in the treated vs the REF group (17.0% vs 32.5%; p = 0.017).
conclusionPregnant women with untreated SCH and without TPOAb positivity had a higher prevalence of pre-eclampsia and GDM compared with euthyroid women, while this was not the case in women with treated SCH, even when it was initiated after the first trimester.
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