ArticleEuropean journal of nuclear medicine and molecular imaging2023
The feasibility of quantitative assessment of dynamic
Article in European journal of nuclear medicine and molecular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Patlak-PBNT: a simple population-based Patlak model to generate [EJNMMI physics · 2026Article
- Association of PET vascular activity score with Takayasu's arteritis angiographic progression.European journal of nuclear medicine and molecular imaging · 2025Observational
- Self-supervised neural network for Patlak-based parametric imaging in dynamic [European journal of nuclear medicine and molecular imaging · 2025Article
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
purposePET has been demonstrated to be sensitive for detecting active inflammation in Takayasu's arteritis (TAK) patients, but semi-quantitative-based assessment may be susceptible to various biological and technical factors. Absolute quantification via dynamic PET (dPET) may provide a more reliable and quantitative assessment of TAK-active arteries. The purpose of this study was to investigate the feasibility and efficacy of dPET in quantifying TAK-active arteries compared to static PET. MATERIALS AND
methodsThis prospective study enrolled 10 TAK-active patients (fulfilled the NIH criteria) and 5 control participants from March to October 2022. One-hour dPET scan (all TAK and control participants) and delayed static PET scan at 2-h (all TAK patients) were acquired. For 1-h static PET, summed images from 50 to 60 min of the dPET were extracted. PET parameters derived from 1- and 2-h static PET including SUV (SUV
resultsBased on the disease states, 5 cases of TAK were classified as untreated and relapsed, respectively. The SUV
conclusionsAbsolute quantitative assessment by dPET provides an improved sensitivity and detectability in both visualization and quantification of TAK-active arteries. This elucidates the clinical significance of dPET in the early detection of active inflammation and monitoring recurrence.
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