Evidence map›Paper›PMID 37690738›Full record

ArticleAnnals of epidemiology2023

Mortality associated with bacterial and fungal infections and overdose among people with drug use diagnoses.

Mary C Figgatt, Asher J Schranz, Bradford E Jackson, Nabarun Dasgupta, Juan M Hincapie-Castillo, Christopher Baggett, Stephen W Marshall, Yvonne M Golightly

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mary C FiggattDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill; Injury Prevention Research Center, University of North Carolina at Chapel Hill, Chapel Hill. Electronic address: maryfiggatt@gmail.com.
Asher J SchranzDepartment of Infectious Diseases, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill.
Bradford E JacksonLineberger Cancer Center Cancer Information and Population Health Resource, University of North Carolina at Chapel Hill, Chapel Hill.
Nabarun DasguptaInjury Prevention Research Center, University of North Carolina at Chapel Hill, Chapel Hill; Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill.
Juan M Hincapie-CastilloDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill.
Christopher BaggettDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill; Lineberger Cancer Center Cancer Information and Population Health Resource, University of North Carolina at Chapel Hill, Chapel Hill.
Stephen W MarshallDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill; Injury Prevention Research Center, University of North Carolina at Chapel Hill, Chapel Hill.
Yvonne M GolightlyDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill; College of Allied Health Professions, University of Nebraska Medical Center, Omaha.
University of North Carolina at Chapel Hill · USUniversity of Nebraska Medical Center · US

Funding

Drug-use associated infective endocarditis: Post-hospitalization outcomes and patient treatment preferencesK23DA049946 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SCHRANZ, ASHER JACOB · 2020 to 2024
$880k
Infections and Drug Use-Related Morbidity and Mortality among People Who Use DrugsF31DA055345 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FIGGATT, MARY CHARLOT · 2022 to 2023
$60k
NIDA NIH HHS F31 DA055345NIDA NIH HHS K23 DA049946
6 · The paper itself

Abstract

purposeHospital visits for drug use-related bacterial and fungal infections have increased alongside overdose deaths. The incidence of mortality from these infections and the comparison to overdose mortality is not established.

methodsThis cohort study examined mortality outcomes among adults with drug use diagnoses who were insured by public and private plans during 2007 through 2018 in North Carolina. We examined bacterial- and fungal infection-related mortality and overdose mortality using cumulative incidence functions.

resultsAmong 131,522 people with drug use diagnoses, the median age was 45 years (interquartile range: 31-57), 58% were women and 65% had an opioid use disorder diagnosis. The 1-year incidence of bacterial and fungal infection-associated mortality was progressively higher as age increased (35-49 years: 9 per 10,000 people, 50-64 years: 23 per 10,000, 65+ years: 50 per 10,000 people). Conversely, the 1-year incidence of overdose mortality was markedly lower among older adults compared to those under the age of 65 (18-34 years: 34 deaths per 10,000 people; 35-49 years: 47 per 10,000; 50-64 years: 41 per 10,000; 65+ years: 9 per 10,000).

conclusionsBacterial and fungal infections and overdose were notable causes of death among adults with drug use diagnoses, and varied by age group.

Indexed as

Drug OverdoseMycosesOpioid-Related DisordersAdultAgedAnalgesics, OpioidCohort StudiesFemaleHumansMaleMiddle AgedNorth CarolinaAnalgesics, OpioidBacterial infectionsDrug overdoseInjection drug useMortalityOpioid use disorder

Identifiers

PMID37690738
PMCPMC10843512
OpenAlexW4386565805

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.