Evidence map›Paper›PMID 37690688›Full record

ArticleThe Journal of biological chemistry2023

Cardiolipin prolongs the lifetimes of respiratory proteins in Drosophila flight muscle.

Mindong Ren, Yang Xu, Colin K L Phoon, Hediye Erdjument-Bromage, Thomas A Neubert, Michael Schlame

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mindong RenDepartments of Anesthesiology, Physiology, New York University Grossman School of Medicine, New York, New York, USA; Departments of Cell Biology, Physiology, New York University Grossman School of Medicine, New York, New York, USA. Electronic address: mindong.ren@nyulangone.org.
Yang XuDepartments of Anesthesiology, Physiology, New York University Grossman School of Medicine, New York, New York, USA.
Colin K L PhoonDepartments of Pediatrics, Physiology, New York University Grossman School of Medicine, New York, New York, USA.
Hediye Erdjument-BromageDepartments of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, New York, USA.
Thomas A NeubertDepartments of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, New York, USA.
Michael SchlameDepartments of Anesthesiology, Physiology, New York University Grossman School of Medicine, New York, New York, USA; Departments of Cell Biology, Physiology, New York University Grossman School of Medicine, New York, New York, USA. Electronic address: michael.schlame@med.nyu.edu.
New York University · US

Funding

Protein Mass Spectrometry Core Facility for NeuroscienceP30NS050276 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NEUBERT, THOMAS A · 2005 to 2015
$7.9M
Aberrant Cardiolipin Dynamics in Barth Syndrome - Renewal - 1R01GM115593 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SCHLAME, MICHAEL · 2015 to 2023
$2.9M
LTQ-Orbitrap Mass Spectrometer.S10RR027990 · NCRR · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NEUBERT, THOMAS A · 2011 to 2011
$600k
Mass Spectrometer For Small Molecule AnalysisS10OD023659 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NEUBERT, THOMAS A · 2017 to 2017
$596k
NCRR NIH HHS S10 RR027990NIGMS NIH HHS R01 GM115593NIH HHS S10 OD023659NINDS NIH HHS P30 NS050276
6 · The paper itself

Abstract

Respiratory complexes and cardiolipins have exceptionally long lifetimes. The fact that they co-localize in mitochondrial cristae raises the question of whether their longevities have a common cause and whether the longevity of OXPHOS proteins is dependent on cardiolipin. To address these questions, we developed a method to measure side-by-side the half-lives of proteins and lipids in wild-type Drosophila and cardiolipin-deficient mutants. We fed adult flies with stable isotope-labeled precursors (

Indexed as

CardiolipinsAnimalsDrosophila melanogasterMitochondriaMitochondrial MembranesMusclesCardiolipinsinsectisotopic tracerlipid–protein interactionmembrane biogenesismitochondrial respiratory chain complex

Identifiers

PMID37690688
PMCPMC10622840
OpenAlexW4386570382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.