Evidence map›Paper›PMID 37690446›Full record

ArticleStereotactic and functional neurosurgery2023

Hemorrhagic Safety of Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Tremor without Interruption of Antiplatelet or Anticoagulant Therapy.

Rose M Caston, Justin M Campbell, Shervin Rahimpour, Paolo Moretti, Matthew D Alexander, John D Rolston

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stereotactic and functional neurosurgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Guideline
  2. Surgical Treatment of Tremor Syndromes: A Guide to the Clinician.Movement disorders clinical practice · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Rose M CastonDepartment of Biomedical Engineering, University of Utah, Salt Lake City, Utah, USA.
Justin M CampbellDepartment of Neurosurgery, University of Utah, Salt Lake City, Utah, USA.
Shervin RahimpourDepartment of Biomedical Engineering, University of Utah, Salt Lake City, Utah, USA.
Paolo MorettiDepartment of Neurology, University of Utah, Salt Lake City, Utah, USA.
Matthew D AlexanderDepartment of Neurosurgery, University of Utah, Salt Lake City, Utah, USA.
John D RolstonDepartment of Biomedical Engineering, University of Utah, Salt Lake City, Utah, USA.
University of Utah · USGeorge E. Wahlen Department of VA Medical Center · USHarvard University · US

Funding

Training in the Development of Novel Interventions for the Treatment of Neurological and Neurobehavioral DisordersT32NS115723 · NINDS · UNIVERSITY OF UTAH · PI KEEFE, KRISTEN A · 2020 to 2024
$1.1M
Patient-Specific Modeling and Network Perturbation to Enhance the Predictability of Direct Cortical Stimulation for EpilepsyK23NS114178 · NINDS · UNIVERSITY OF UTAH · PI ROLSTON, JOHN D · 2019 to 2023
$961k
NINDS NIH HHS K23 NS114178NINDS NIH HHS T32 NS115723
6 · The paper itself

Abstract

introductionMagnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is an incision-less ablative technique used to treat medically refractory tremor. Although intracerebral hemorrhage has not been reported with MRgFUS thalamotomy for the treatment of movement disorders, clinicians commonly interrupt active blood thinning medications prior to the procedure or offer gamma knife radiosurgery instead. However, MRgFUS uses focal thermoablation, and bleeding risk is likely minimal. This study aimed to evaluate the safety of MRgFUS thalamotomy in patients with essential tremor (ET) and tremor-dominant Parkinson's disease (PD) without interrupting anticoagulant or antiplatelet therapies.

methodsThis was a single-center retrospective case series of all patients with ET or PD undergoing MRgFUS from February 2019 through December 2022 (n = 96). Demographic variables and medications taken at the time of surgery were obtained. Our primary outcome was the type and frequency of hemorrhagic complications noted on the operative report or postoperative imaging.

resultsThe mean age of patients was 74.2 years, and 26% were female. Forty patients were taking ≥1 antiplatelet or anticoagulant medications. No patient actively taking anticoagulant or antiplatelet therapies had a hemorrhagic complication during or <48 h after the procedure.

conclusionThe frequency of intra- or postoperative complications from MRgFUS was not higher in patients actively taking anticoagulant or antiplatelet therapies relative to those who were not. Our findings suggest that MRgFUS thalamotomy does not necessitate interrupting anticoagulant or antiplatelet therapies. However, given the limited number of patients actively taking these therapies in our cohort (n = 40), additional testing in large, prospective studies should be conducted to further establish safety.

Indexed as

Essential TremorParkinson DiseaseAgedAnticoagulantsFemaleHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleProspective StudiesRetrospective StudiesThalamusTreatment OutcomeTremorAnticoagulantsFocused ultrasoundHemorrhagic riskMagnetic resonance-guided focused ultrasoundNoninvasive methodThalamotomyTremor

Identifiers

PMID37690446
PMCPMC10591802
OpenAlexW4386592476

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.