Evidence map›Paper›PMID 37689808›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2024

Resuscitation, survival and morbidity of extremely preterm infants in California 2011-2019.

Brennan V Higgins, Rebecca J Baer, Martina A Steurer, Kayla L Karvonen, Scott P Oltman, Laura L Jelliffe-Pawlowski, Elizabeth E Rogers

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06893939 (Limited Versus Extended Trophic Feeding), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06893939 phase2 / phase3recruitingnot on this mapstarted 2025, after this paper: background citation

Limited Versus Extended Trophic Feeding (LET-FEED) Trial

TypeinterventionalSponsorUniversity of WashingtonRan2025 to 2031Enrolled350ConditionsSepsis, Length of Stay, Mortality, Neurodevelopmental DelayArmsLimited Trophic Feeds (1 day of trophic feeds), Extended Trophic Feeds (3 days of trophics)
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. NewbornGenes · 2025
    Pooled it
  2. Pooled it
  3. Trial
  4. Neurodevelopmental outcomes at age 3 years of preterm infants born at 22-31 weeks' gestation.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Trial
  5. Observational
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Bacterial and fungal infections in infants born before 24 weeks' gestation: a review.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Variation in NICU utilization: a narrative review and path forward.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Brennan V HigginsDivision of Neonatology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA. Brennan.higgins@ucsf.edu.ORCID 0000-0002-8304-6658
Rebecca J BaerCalifornia Preterm Birth Initiative, University of California, San Francisco, San Francisco, CA, USA.
Martina A SteurerDivision of Neonatology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-0794-160X
Kayla L KarvonenDivision of Neonatology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8213-6697
Scott P OltmanCalifornia Preterm Birth Initiative, University of California, San Francisco, San Francisco, CA, USA.
Laura L Jelliffe-PawlowskiCalifornia Preterm Birth Initiative, University of California, San Francisco, San Francisco, CA, USA.
Elizabeth E RogersDivision of Neonatology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.
University of California, San Francisco · US

Funding

Transdisciplinary Research Training to Reduce Disparities in Preterm Birth and Improve Maternal and Neonatal OutcomesT32HD098057 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KUPPERMANN, MIRIAM · 2019 to 2023
$1.4M
NICHD NIH HHS T32 HD098057
6 · The paper itself

Abstract

objectiveTo describe changes over time in resuscitation, survival, and morbidity of extremely preterm infants in California. STUDY

designThis population-based, retrospective cohort study includes infants born ≤28 weeks. Linked birth certificates and hospital discharge records were used to evaluate active resuscitation, survival, and morbidity across two epochs (2011-2014, 2015-2019).

resultsOf liveborn infants, 0.6% were born ≤28 weeks. Active resuscitation increased from 16.9% of 22-week infants to 98.1% of 25-week infants and increased over time in 22-, 23-, and 25-week infants (p-value ≤ 0.01). Among resuscitated infants, survival to discharge increased from 33.2% at 22 weeks to 96.1% at 28 weeks. Survival without major morbidity improved over time for 28-week infants (p-value < 0.01).

conclusionAmong infants ≤28 weeks, resuscitation and survival increased with gestational age and morbidity decreased. Over time, active resuscitation of periviable infants and morbidity-free survival of 28-week infants increased. These trends may inform counseling around extremely preterm birth.

Indexed as

Infant, Premature, DiseasesPremature BirthFemaleGestational AgeHumansInfantInfant, Extremely PrematureInfant MortalityInfant, NewbornMorbidityResuscitationRetrospective Studies

Identifiers

PMID37689808
PMCPMC10844092
OpenAlexW4386571371

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.