Evidence map›Paper›PMID 37689665›Full record

SynthesisBMC oral health2023

The impact of periodontal disease on the clinical outcomes of COVID-19: A systematic review and meta-analysis.

Sadeq Ali Al-Maweri, Mohammed Nasser Alhajj, Esam Halboub, Faleh Tamimi, Nosizana Mohd Salleh, Mohammed Sultan Al-Ak'hali, Saba Kassim, Saleem Abdulrab, Lamyia Anweigi, Marwan Mansoor Ali Mohammed

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 5 countries.

Sadeq Ali Al-MaweriCollege of Dental Medicine, QU Health, Qatar University, Doha, Qatar. Sadali05@hotmail.com.
Mohammed Nasser AlhajjDepartment of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Federal Territory of Kuala Lumpur, Kuala Lumpur, Malaysia.
Esam HalboubDepartment of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
Faleh TamimiCollege of Dental Medicine, QU Health, Qatar University, Doha, Qatar.
Nosizana Mohd SallehDepartment of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Federal Territory of Kuala Lumpur, Kuala Lumpur, Malaysia.
Mohammed Sultan Al-Ak'haliDepartment of Preventive Dental Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia.
Saba KassimDepartment of Preventive Dental Sciences, College of Dentistry, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia.
Saleem AbdulrabAl Khor Health Center, Primary Health Care Corporation, Doha, Qatar.
Lamyia AnweigiCollege of Dental Medicine, QU Health, Qatar University, Doha, Qatar.
Marwan Mansoor Ali MohammedDepartment of Oral and Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Qatar University · QAJazan University · SAUniversity of Malaya · MYPrimary Health Care · QATaibah University · SAUniversity of Sharjah · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA possible relationship between periodontitis (PD) and COVID-19 and its adverse outcomes has been suggested. Hence, the present systematic review and meta-analysis aimed to investigate the available evidence regarding the potential association between periodontitis (PD) and COVID-19 and its adverse outcomes. MATERIALS AND

methodsPubMed, Scopus, Web of Science, and Google Scholar were searched for relevant studies published up to April 15

resultsA total of 22 studies involving 92,535 patients from USA, Europe, Asia, the Middle East and South America were included; of these, 12 were pooled into the meta-analysis. Most of the studies (19 studies) reported a significant association between PD and COVID-19. The pooled data found a significant association between PD and COVID-19 outcomes: more severe symptoms (OR = 6.95, P = 0.0008), ICU admissions (OR = 3.15, P = 0.0001), and mortality (OR = 1.92, P = 0.21). Additionally, compared to mild PD, severe PD was significantly associated with higher risks of severe COVID-19 outcomes: severe symptoms (P = 0.02); ICU admission (P = 0.0001); and higher mortality rates (P = 0.0001). The results also revealed 58% higher risk for COVID-19 infection in patients with PD (P = 0.00001).

conclusionsThe present findings suggest a possible association between poor periodontal health and the risk of poor COVID-19 outcomes. However, owing to the observed methodological heterogeneity across the included studies, further prospective cohort studies with standardized methodologies are warranted to further unravel the potential association between periodontal disease and COVID-19 and its adverse outcomes.

Indexed as

COVID-19Periodontal DiseasesEuropeHospitalizationHumansProspective StudiesAssociationCOVID-19 outcomesPeriodontal diseaseSystematic review

Identifiers

PMID37689665
PMCPMC10493030
OpenAlexW4386568872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.