Evidence map›Paper›PMID 37689062›Full record

ArticleCell systems2023

Synthetic symmetry breaking and programmable multicellular structure formation.

Noreen Wauford, Akshay Patel, Jesse Tordoff, Casper Enghuus, Andrew Jin, Jack Toppen, Melissa L Kemp, Ron Weiss

Open access · greenAbstract read
In one paragraph

Article in Cell systems, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Totipotency or plenipotency: rethinking stem cell bipotentiality.Current opinion in genetics & development · 2025
    Review
  6. Review
  7. Open problems in synthetic multicellularity.NPJ systems biology and applications · 2024
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Noreen WaufordDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Akshay PatelDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jesse TordoffProgram in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Casper EnghuusDepartment of Microbiology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Andrew JinThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Jack ToppenSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Melissa L KempThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Ron WeissDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Electrical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: rweiss@mit.edu.
Massachusetts Institute of Technology · USGeorgia Institute of Technology · US

Funding

Synthetic gene sensors and effectors to redirect organoid developmentR01EB030946 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELTA, CALIN, KEMP, MELISSA LAMBETH · 2021 to 2024
$2.6M
Programmed Differentiation Circuits for Organoids using Meso-MicrofluidicsR01EB025256 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CARR, PETER ANDREW · 2018 to 2021
$2.4M
NIBIB NIH HHS R01 EB025256NIBIB NIH HHS R01 EB030946
6 · The paper itself

Abstract

During development, cells undergo symmetry breaking into differentiated subpopulations that self-organize into complex structures.

Indexed as

EngineeringOrganoidsCell AdhesionCell DifferentiationProbabilityadhesionagent-based modelbiophysicsmorphogenesissimulationssymmetry breakingsynthetic biology

Identifiers

PMID37689062
PMCPMC10919224
OpenAlexW4386558937

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.