SynthesisEndocrine2024
A systematic review and meta-analysis investigating the relationship between metabolic syndrome and the incidence of thyroid diseases.
Synthesis in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07126353 (Metabolic Risk Assessment in Prepubertal Children With Congenital Hypothyroidism), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metabolic Risk Assessment in Prepubertal Children With Congenital Hypothyroidism (IpoMet)
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of overt hypothyroidism and subclinical hypothyroidism in metabolic syndrome: a systematic review and meta-analysis.BMC endocrine disorders · 2026Pooled it
- Epidemiological Patterns and Determinants of Subclinical and Overt Hypothyroidism in a Clinical Cohort from the Hail Region, Saudi Arabia: A Retrospective Cross-Sectional and Cluster Analysis Study.Clinics and practice · 2026Article
- The complexity of the relationship between thyroid disease and body weight.Nature reviews. Endocrinology · 2026Review
- Association between cardiometabolic index and thyroid function: insights from NHANES.Hormones (Athens, Greece) · 2026Article
- Analysis of the association between water iodine concentration and TyG-BMI index with thyroid diseases: a cross-sectional study in Shandong province, China.Frontiers in nutrition · 2026Article
- Clinical and metabolic links between hypothyroidism and metabolic syndrome: a review.Frontiers in endocrinology · 2026Review
- Sex differences in thyroid aging and their implications in thyroid disorders: insights from gene regulatory networks.bioRxiv : the preprint server for biology · 2025Article
- Thyroid Disorders and Their Impact on Metabolic Syndrome and Cardiovascular Risk: A Narrative Review.Cureus · 2025Review
- Incidence of Subclinical Hypothyroidism in Obese Adults and Its Metabolic Implications: A Prospective Cohort Study.Cureus · 2025Article
- Thyroid Hormones and Metabolism Regulation: Which Role on Brown Adipose Tissue and Browning Process?Biomolecules · 2025Review
- A Real-Life Study in Patients Newly Diagnosed with Autoimmune Hashimoto's Thyroiditis: Analysis of Asthenia as Admission Complaint.Life (Basel, Switzerland) · 2024Article
- Metabolic Syndrome, Thyroid Dysfunction, and Cardiovascular Risk: The Triptych of Evil.International journal of molecular sciences · 2024Review
- Obesity and Obesity-Related Thyroid Dysfunction: Any Potential Role for the Very Low-Calorie Ketogenic Diet (VLCKD)?Current nutrition reports · 2024Review
- Subclinical Hypothyroidism in Patients with Obesity and Metabolic Syndrome: A Narrative Review.Nutrients · 2023Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeTo assess the prospective association between metabolic syndrome (MetS), its components, and incidence of thyroid disorders by conducting a systematic review and meta-analysis.
methodsA systematic search was performed in Ovid Medline, Embase.com, and Cochrane CENTRAL from inception to February 22, 2023. Publications from prospective studies were included if they provided data on baseline MetS status or one of its components and assessed the incidence of thyroid disorders over time. A random effects meta-analysis was conducted to calculate the odds ratio (OR) for developing thyroid disorders.
resultsAfter full-text screening of 2927 articles, seven studies met our inclusion criteria. Two of these studies assessed MetS as an exposure (N = 71,727) and were included in our meta-analysis. The association between MetS at baseline and incidence of overt hypothyroidism at follow-up yielded an OR of 0.78 (95% confidence interval [CI]: 0.52-1.16 for two studies, I
conclusionsWe were unable to draw firm conclusions regarding the association between MetS and the incidence of thyroid disorders due to the limited number of available studies and the presence of important heterogeneity in reporting results. However, we did find an association between obesity at baseline and incidence of overt and subclinical hypothyroidism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.