Evidence map›Paper›PMID 37688680›Full record

ArticleMolecular biology reports2023

Association between polymorphisms of TLR2-1-6 and bipolar disorder in a tunisian population.

Youssef Aflouk, Oumaima Inoubli, Amira Kenz, Saloua Yacoub, Ferid Zaafrane, Lotfi Gaha, Besma Bel Hadj Jrad

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In one paragraph

Article in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Youssef AfloukLaboratory of Genetics, Biodiversity, and Valorization of Bioresources GBVB (LR11ES41), Higher Institute of Biotechnology of Monastir (ISBM), University of Monastir, Monastir, 5000, Tunisia. afloukyoussef1@gmail.com.ORCID http://orcid.org/0000-0002-1155-4039
Oumaima InoubliLaboratory of Genetics, Biodiversity, and Valorization of Bioresources GBVB (LR11ES41), Higher Institute of Biotechnology of Monastir (ISBM), University of Monastir, Monastir, 5000, Tunisia.
Amira KenzLaboratory of Genetics, Biodiversity, and Valorization of Bioresources GBVB (LR11ES41), Higher Institute of Biotechnology of Monastir (ISBM), University of Monastir, Monastir, 5000, Tunisia.
Saloua YacoubRegional Center of Blood Transfusion, University Hospital Farhat Hached, Sousse, Tunisia.
Ferid ZaafraneDepartment of Psychiatry and Vulnerability to Psychoses Laboratory-CHU Fattouma Bourguiba Monastir, University of Monastir, Monastir, Tunisia.
Lotfi GahaDepartment of Psychiatry and Vulnerability to Psychoses Laboratory-CHU Fattouma Bourguiba Monastir, University of Monastir, Monastir, Tunisia.
Besma Bel Hadj JradLaboratory of Genetics, Biodiversity, and Valorization of Bioresources GBVB (LR11ES41), Higher Institute of Biotechnology of Monastir (ISBM), University of Monastir, Monastir, 5000, Tunisia.
University of Monastir · TNHôpital Farhat Hached · TN

Funding

Ministère de l'Enseignement Supérieur et de la Recherche Scientifique Ministère de l'Enseignement Supérieur et de la Recherche Scientifique
6 · The paper itself

Abstract

backgroundBipolar disorder (BD) is a complex neuropsychiatric disease that has been strongly linked to immune dysregulation. In particular, an abnormal inflammatory response mediated by toll-like receptor 2 - 1/6 (TLR2-1/6) was described in BD. Nevertheless, genetic factors' contribution is still unknown. Thus, we suggested that functional polymorphisms of TLR2, 1 and 6 could be involved in BD predisposition. METHODS AND

resultsTLR2, 1 and 6 polymorphisms were genotyped by PCR-RFLP in 292 controls and 131 patients from a Tunisian population. Polymorphisms and haplotype associations were explored in BD and binary logistic regression analysis was performed for more powerful associations. In dominant model, we found a significantly higher genotype and minor allele frequencies in healthy females compared to patients for TLR2-196-174Ins/Del (p = 0.04; OR = 0.3, p = 0.04; OR = 0.3, respectively) and for TLR6-S249P only with minor allele (p = 0.03; OR = 0.2). In contrast, TLR2-R677W CT + TT and T allele frequencies were significantly higher in BD (p

conclusionsWe suggest that TLR2-196-174Ins/Del and TLR6-S249P could be protective factors of females against BD. However, TLR2-R677W and TLR1-R80T could be strongly associated with higher risk of BD. Interestingly, TLR2-R677W could be a genetic marker for BD in females. However, further studies with larger groups are needed to confirm these findings.

Indexed as

Bipolar DisorderToll-Like Receptor 2Case-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotideToll-Like Receptor 1Toll-Like Receptor 6TLR2 protein, humanToll-Like Receptor 1Toll-Like Receptor 2Toll-Like Receptor 6Bipolar disorderPolymorphismTLR1TLR2TLR6

Identifiers

PMID37688680
OpenAlexW4386569100

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.