Evidence map›Paper›PMID 37688120›Full record

ArticlePolymers2023

A Straightforward Method to Produce Multi-Nanodrug Delivery Systems for Transdermal/Tympanic Patches Using Electrospinning and Electrospray.

Bahareh Azimi, Claudio Ricci, Teresa Macchi, Cemre Günday, Sara Munafò, Homa Maleki, Federico Pratesi, Veronika Tempesti, Caterina Cristallini, Luca Bruschini and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Bahareh AzimiDepartment of Civil and Industrial Engineering, University of Pisa, Largo L. Lazzarino 2, 56122 Pisa, Italy.ORCID 0009-0006-4384-4926
Claudio RicciDepartment of Civil and Industrial Engineering, University of Pisa, Largo L. Lazzarino 2, 56122 Pisa, Italy.ORCID 0000-0002-0110-8836
Teresa MacchiDepartment of Translational Researches and New Technologies in Medicine and Surgery, via Savi 10, 56126 Pisa, Italy.
Cemre GündayMyBiotech GmbH, Industriestrasse 1B, 66802 Überherrn, Germany.
Sara MunafòDepartment of Civil and Industrial Engineering, University of Pisa, Largo L. Lazzarino 2, 56122 Pisa, Italy.
Homa MalekiDepartment of Carpet, Faculty of Arts, University of Birjand, Birjand 9717434765, Iran.
Federico PratesiDepartment of Translational Researches and New Technologies in Medicine and Surgery, via Savi 10, 56126 Pisa, Italy.ORCID 0000-0002-7226-0907
Veronika TempestiConsorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM), via G. Giusti 9, 50121 Florence, Italy.
Caterina CristalliniConsorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM), via G. Giusti 9, 50121 Florence, Italy.
Luca BruschiniDepartment of Surgical, Medical, Molecular Pathology and Emergency Medicine, University of Pisa, via Savi 10, 56126 Pisa, Italy.ORCID 0000-0002-6900-1306
Andrea LazzeriDepartment of Civil and Industrial Engineering, University of Pisa, Largo L. Lazzarino 2, 56122 Pisa, Italy.ORCID 0000-0002-9463-1502
Serena DantiDepartment of Civil and Industrial Engineering, University of Pisa, Largo L. Lazzarino 2, 56122 Pisa, Italy.ORCID 0000-0002-8155-8537
Nazende Günday-TüreliMyBiotech GmbH, Industriestrasse 1B, 66802 Überherrn, Germany.ORCID 0000-0002-6310-4785
University of Pisa · ITInstitute for Chemical and Physical Processes · ITNational Interuniversity Consortium of Materials Science and Technology · ITUniversity of Tehran · IR

Funding

European Commission 4NanoEARDRM - EuroNanoMed III, ERA-NET Cofund Horizon 2020Federal Ministry of Education and Research 13XP5061A (4NanoEARDRM project - cofund)Ministry of Education, Universities and Research B56H18000140001 (4NanoEARDRM project - cofund)
6 · The paper itself

Abstract

The delivery of drugs through the skin barrier at a predetermined rate is the aim of transdermal drug delivery systems (TDDSs). However, so far, TDDS has not fully attained its potential as an alternative to hypodermic injections and oral delivery. In this study, we presented a proof of concept of a dual drug-loaded patch made of nanoparticles (NPs) and ultrafine fibers fabricated by using one equipment, i.e., the electrospinning apparatus. Such NP/fiber systems can be useful to release drugs locally through the skin and the tympanic membrane. Briefly, dexamethasone (DEX)-loaded poly(3-hydroxybutyrate-

Indexed as

bio-basedcontrolled drug releasedexamethasoneeardrumfibershuman dermal fibroblastsnanoparticlespoly(hydroxybutyrate-co-hydroxyvalerate) (PHBHV)poly(lactic-glycolic acid) (PLGA)rhodamine

Identifiers

PMID37688120
PMCPMC10490036
OpenAlexW4386051143

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.