ArticleMaterials (Basel, Switzerland)2023
Synthesis and Characterization of Agarose Hydrogels for Release of Diclofenac Sodium.
Article in Materials (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Advances in 3D Bioprinting: Materials, Processes, and Emerging Applications.Micromachines · 2026Review
- Bacterial ghosts embedded in natural hydrogels as drug delivery vehicles for cancer treatment.RSC advances · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Hydrogels are attractive biomaterials for the controlled release of various pharmaceuticals, due to their ability to embed biologically active moieties in a 3D polymer network. Among them, agarose-based hydrogels are an interesting, but still not fully explored, group of potential platforms for controlled drug release. In this work, agarose hydrogels with various contents of citric acid were prepared, and their mechanical and physicochemical properties were investigated using various instrumental techniques, such as rheological measurements, attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR). Releasing tests for diclofenac sodium (DICL) were run in various environments; water, PBS, and 0.01 M NaOH; which remarkably affected the profile of the controlled release of this model drug. In addition to affecting the mechanical properties, the amount of citric acid incorporated within a hydrogel network during synthesis was also of great importance to the rate of DICL release. Therefore, due to their high biocompatibility, agarose hydrogels can be regarded as safe and potential platforms for controlled drug release in biomedical applications.
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