Evidence map›Paper›PMID 37686778›Full record

ArticleNutrients2023

Olive Mill Wastewater as Source of Polyphenols with Nutraceutical Properties.

Doretta Cuffaro, Andrea Bertolini, Simone Bertini, Claudio Ricci, Maria Grazia Cascone, Serena Danti, Alessandro Saba, Marco Macchia, Maria Digiacomo

Abstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Functionalization ofInternational journal of molecular sciences · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Olive Mill Wastewater Extract: In Vitro Genotoxicity/Antigenotoxicity Assessment on HepaRG Cells.International journal of environmental research and public health · 2024
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Doretta CuffaroDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.ORCID 0000-0002-8842-542X
Andrea BertoliniDepartment of Surgery, Medical, Molecular and Critical Area Pathology, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0003-4810-7061
Simone BertiniDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.ORCID 0000-0001-8832-8075
Claudio RicciDepartment of Civil and Industrial Engineering, University of Pisa, 56122 Pisa, Italy.ORCID 0000-0002-0110-8836
Maria Grazia CasconeDepartment of Civil and Industrial Engineering, University of Pisa, 56122 Pisa, Italy.ORCID 0000-0002-0037-7807
Serena DantiDepartment of Civil and Industrial Engineering, University of Pisa, 56122 Pisa, Italy.ORCID 0000-0002-8155-8537
Alessandro SabaInterdepartmental Research Center "Nutraceuticals and Food for Health", University of Pisa, 56100 Pisa, Italy.ORCID 0000-0003-0611-5549
Marco MacchiaDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Maria DigiacomoDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.ORCID 0000-0003-0653-6642

Funding

Ministry of University and Research (MUR) PON 2014-2020 "Research and In-novation" resources - Green/Innovation Action - DM MUR 1062/2021 - Title of research "Sviluppo di una piattaforma tecnologica per lo studio delle propri-età nutraceutiche di biomolecole e biomateriali presenti negli scarti d
6 · The paper itself

Abstract

backgroundAgrifood waste products are often considered rich sources of bioactive compounds that can be conveniently recovered. Due to these peculiar characteristics, the study of these waste products is attracting great interest in nutraceutical research. Olive mill wastewaters (OMWWs) are generated by extra virgin olive oil (EVOO) production, and they pose environmental challenges due to their disposal. This study aimed to characterize the polyphenolic profile and to evaluate the nutraceutical properties of OMWW extracts from two Tuscan olive cultivars, Leccino (CL) and Frantoio (CF), collected during different time points in EVOO production.

methodAfter a liquid-liquid extraction, the HPLC and LC-MS/MS analysis of OMWW extracts confirmed the presence of 18 polyphenolic compounds.

resultsThe polyphenol composition varied between the cultivars and during maturation stages. Notably, oleacein was detected at remarkably high levels in CL1 and CF1 extracts (314.628 ± 19.535 and 227.273 ± 3.974 μg/mg, respectively). All samples demonstrated scavenging effects on free radicals (DPPH and ABTS assays) and an anti-inflammatory potential by inhibiting cyclooxygenase (COX) enzymes.

conclusionsThis study highlights the nutraceutical potential of OMWW extracts, emphasizing their antioxidant, antiradical, and anti-inflammatory activities. The results demonstrate the influence of olive cultivar, maturation stage, and extraction process on the polyphenolic composition and the bioactivity of OMWW extracts. These findings support a more profitable reuse of OMWW as an innovative, renewable, and low-cost source of dietary polyphenols with potential applications as functional ingredients in the development of dietary supplements, as well as in the pharmaceutical and cosmetics industries.

Indexed as

OleaWastewaterChromatography, LiquidDietary SupplementsPlant ExtractsPolyphenolsTandem Mass SpectrometryWaste ProductsPlant ExtractsPolyphenolsWaste ProductsWastewateranti-inflammatory propertiesantioxidantsextra virgin olive oilnutraceuticalsolive mill wastewater

Identifiers

PMID37686778
PMCPMC10489820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.