ArticleNutrients2023
Impact of Homocysteine as a Preconceptional Screening Factor for In Vitro Fertilization and Prevention of Miscarriage with Folic Acid Supplementation Following Frozen-Thawed Embryo Transfer: A Hospital-Based Retrospective Cohort Study.
Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Vitamin B12 and Reproductive Health: Clinical Insights, Emerging Mechanistic Understanding, and Nutritional Aspects.Molecular reproduction and development · 2026Review
- Effect of patient and partner preconceptional nutraceutical supplementation on the onset of natural pregnancy: a retrospective study.Revista da Associacao Medica Brasileira (1992) · 2026Article
- The roles of folate, MTHFR genetics, vitamin B12 in pregnancy outcomes.Frontiers in nutrition · 2026Review
- Article
- Clinical Benefits and Safety of Multiple Micronutrient Supplementation During Preconception, Pregnancy, and Lactation: A Review.Nutrition reviews · 2025Review
- Effects of Homocysteine Circulating Levels on Human Spontaneous Fertility and In Vitro Fertilization Outcomes: A Literature Review.Nutrients · 2025Review
- Vitamin D, Homocysteine, and Thyroid Dysfunction as Risk Factors for Missed Abortion: A Retrospective Risk Factor Analysis.International journal of women's health · 2025Article
- Risk prediction for recurrent pregnancy loss based on routine inspections in the first trimester of pregnancy, a retrospective study in China.Frontiers in medicine · 2025Article
- Placental expression and methylation of angiogenic factors in assisted reproductive technology pregnancies from India.Epigenomics · 2025Article
- Mass spectrometry of water-soluble vitamins to establish a risk model for predicting recurrent spontaneous abortion.Scientific reports · 2024Article
- Micronutrient Antioxidants for Men (MenevitAntioxidants (Basel, Switzerland) · 2024Article
- Is There a Connection between Hyperhomocysteinemia and the Cardiometabolic Syndrome?Biomedicines · 2024Article
- Strategies for Safeguarding High-Risk Pregnancies From Preterm Birth: A Narrative Review.Cureus · 2024Review
- Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Homocysteine is an amino acid naturally produced in the body and metabolized via the methionine cycle. High homocysteine levels can increase the risk of infertility and pregnancy complications, such as preeclampsia, preterm delivery, miscarriage, and low birth weight. Preconceptional homocysteine levels may be reduced by taking folic acid supplements to reduce the risk of such complications. This cross-sectional, hospital-based study was conducted to examine the role of homocysteine in 1060 infertile women with a history of IVF/intracytoplasmic sperm injection (ICSI) failure. We analyzed whether folic acid intervention altered homocysteine levels and influenced reproductive outcome. We found that a higher homocysteine level was statistically associated with a lower fertilization rate in patients with a history of IVF/ICSI failure. There was an inverse relationship between homocysteine levels and serum 25(OH)VD, and a trend towards lower anti mullerian hormone in the group with higher homocysteine levels. This is the first interventional study to identify that folic acid supplementation improved pregnancy outcomes following freeze embryo transfer (FET) in women with a history of FET failure by monitoring the reduction in homocysteine levels. Therefore, folic acid supplementation and homocysteine level monitoring may constitute a novel intervention for improving IVF/ICSI pregnancy outcomes.
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