Evidence map›Paper›PMID 37686683›Full record

ArticleCancers2023

Association of Fibrinolytic Potential and Risk of Mortality in Cancer Patients.

Gabriele Silva Souza Gois, Silmara Aparecida Lima Montalvão, Thaizy Ramires Alencar Anhaia, Millene Evelyn Alves Almeida, Beatriz Moraes Martinelli, Maria Carmen Gonçalves Lopes Fernandes, Stephany Cares Hubers, Monique R M Ferreira, Daniel Dias Ribeiro, Júlio César Teixeira and 14 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 3 institutions in 1 country.

Gabriele Silva Souza GoisSchool of Medical Science, FCM-UNICAMP, University of Campinas, Campinas 13083-888, SP, Brazil.ORCID 0000-0002-4032-4304
Silmara Aparecida Lima MontalvãoLaboratory of Hemostasis, Hematology and Transfusion Medicine Center, Hemocentro-UNICAMP, Campinas 13083-878, SP, Brazil.
Thaizy Ramires Alencar AnhaiaSchool of Medical Science, FCM-UNICAMP, University of Campinas, Campinas 13083-888, SP, Brazil.
Millene Evelyn Alves AlmeidaLaboratory of Hemostasis, Hematology and Transfusion Medicine Center, Hemocentro-UNICAMP, Campinas 13083-878, SP, Brazil.
Beatriz Moraes MartinelliLaboratory of Hemostasis, Hematology and Transfusion Medicine Center, Hemocentro-UNICAMP, Campinas 13083-878, SP, Brazil.
Maria Carmen Gonçalves Lopes FernandesLaboratory of Hemostasis, Hematology and Transfusion Medicine Center, Hemocentro-UNICAMP, Campinas 13083-878, SP, Brazil.
Stephany Cares HubersLaboratory of Hemostasis, Hematology and Transfusion Medicine Center, Hemocentro-UNICAMP, Campinas 13083-878, SP, Brazil.
Monique R M FerreiraLaboratory of Hemostasis, Hematology and Transfusion Medicine Center, Hemocentro-UNICAMP, Campinas 13083-878, SP, Brazil.ORCID 0000-0002-2621-0255
Daniel Dias RibeiroClinical Hospital of UFMG, Belo Horizonte 30130-100, MG, Brazil.
Júlio César TeixeiraDepartment of Obstetrics and Gynecology, Division of Oncology, Women's Hospital, CAISM-UNICAMP, University of Campinas, Campinas 13083-881, SP, Brazil.ORCID 0000-0002-0979-376X
José Barreto Campello CarvalheiraClinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil.ORCID 0000-0002-0136-0943
Carmen Silvia Passos LimaClinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil.
Nelson Adami AndreolloClinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil.
Maurício EtchebehereClinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil.ORCID 0000-0002-5176-2369
Lair ZambonClinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil.
Ubirajara FerreiraClinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil.
Alfio José TincaniClinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil.
Antônio Santos MartinsClinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil.
Cláudio Saddy Rodrigues CoyClinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil.
José Cláudio Teixeira SeabraClinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil.
Ricardo Kalaf MussiClinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil.
Helder TedeschiClinical Hospital of Unicamp, Campinas 13083-888, SP, Brazil.
Joyce Maria Anninchino-BizzacchiSchool of Medical Science, FCM-UNICAMP, University of Campinas, Campinas 13083-888, SP, Brazil.
Adventh Cancer Group
Hospital de Clínicas da Unicamp · BRUniversidade Estadual de Campinas (UNICAMP) · BRHospital das Clínicas da Universidade Federal de Minas Gerais · BR

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 88887489782/2020-00São Paulo Research Foundation 2016/14172-6
6 · The paper itself

Abstract

Cancer is a leading cause of death, and the fibrinolytic system shows cooperative effects that facilitate the growth of tumors and the appearance of metastases. This prospective study aimed to evaluate the fibrinolytic potential in cancer patients and its association with mortality outcomes using the fluorometric method of simultaneous thrombin and plasmin generation. The study included 323 cancer patients and 148 healthy individuals. During the 12-month follow-up, 68 patients died. Compared to the control group, cancer patients showed alterations in thrombin production consistent with a hypercoagulability profile, and an increase in plasmin generation. Mortality risk was associated with two parameters of thrombin in both univariate and multivariable analysis: maximum amplitude (Wald 11.78,

Indexed as

cancerfibrinolysismortalityplasminSTPthrombin

Identifiers

PMID37686683
PMCPMC10487037
OpenAlexW4386410330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.