Evidence map›Paper›PMID 37686649›Full record

ReviewCancers2023

Ibero-American Consensus Review and Incorporation of New Biomarkers for Clinical Practice in Colorectal Cancer.

Carlos Eduardo Bonilla, Paola Montenegro, Juan Manuel O'Connor, Ovidio Hernando-Requejo, Enrique Aranda, José Pinto Llerena, Alejandra Llontop, Jorge Gallardo Escobar, María Del Consuelo Díaz Romero, Yicel Bautista Hernández and 4 more

Abstract readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Carlos Eduardo BonillaFundación CTIC-Centro de Tratamiento e Investigación sobre Cáncer, Bogotá 1681442, Colombia.ORCID 0000-0002-6323-9612
Paola MontenegroInstitución AUNA OncoSalud e Instituto Nacional de Enfermedades Neoplásicas, Lima 15023, Peru.ORCID 0000-0002-1484-9537
Juan Manuel O'ConnorInstituto Alexander Fleming, Buenos Aires C1426, Argentina.ORCID 0000-0002-6975-5466
Ovidio Hernando-RequejoCentro Integral Oncológico Clara Campal, HM Hospitales, 28660 Madrid, Spain.ORCID 0000-0002-9615-9686
Enrique ArandaDepartamento de Oncología Médica, Hospital Reina Sofía, IMIBIC, UCO, CIBERONC, 14004 Cordoba, Spain.
José Pinto LlerenaInstituto Oncológico Nacional, Panama City 0816, Panama.ORCID 0000-0003-2200-2376
Alejandra LlontopInstituto de Oncología Ángel H. Roffo, Ciudad Autónoma de Buenos Aires C1437FBG, Argentina.
Jorge Gallardo EscobarClínica Las Condes, Santiago de Chile 7591047, Chile.
María Del Consuelo Díaz RomeroInstituto Nacional de Cancerología, Mexico City 14080, Mexico.
Yicel Bautista HernándezHospital General de México, Mexico City 06720, Mexico.
Begoña Graña SuárezServicio de Oncología Médica, Hospital Universitario de A Coruña, Servicio Galego de Saúde (SERGAS), 15006 A Coruña, Spain.
Emilio J BatageljHospital Militar Central de Buenos Aires, Buenos Aires C1426, Argentina.
Ahmad Wali MushtaqServicio de Oncología, Hospital Eugenio Espejo, Quito 170136, Ecuador.
Jesús García-FoncillasHospital Universitario Fundación Jiménez Díaz, Universidad Autónoma de Madrid, 28040 Madrid, Spain.

Funding

Merck (Spain) not availableSociedad Española de Oncología Médica (SEOM) not available
6 · The paper itself

Abstract

Advances in genomic technologies have significantly improved the management of colorectal cancer (CRC). Several biomarkers have been identified in CRC that enable personalization in the use of biologic agents that have shown to enhance the clinical outcomes of patients. However, technologies used for their determination generate massive amounts of information that can be difficult for the clinician to interpret and use adequately. Through several discussion meetings, a group of oncology experts from Spain and several Latin American countries reviewed the latest literature to provide practical recommendations on the determination of biomarkers in CRC based on their clinical experience. The article also describes the importance of looking for additional prognostic biomarkers and the use of histopathology to establish an adequate molecular classification. Present and future of immunotherapy biomarkers in CRC patients are also discussed, together with several techniques for marker determination, including liquid biopsy, next-generation sequencing (NGS), polymerase chain reaction (PCR), and fecal immunohistochemical tests. Finally, the role of Molecular Tumor Boards in the diagnosis and treatment of CRC is described. All of this information will allow us to highlight the importance of biomarker determination in CRC.

Indexed as

biomarkerscolorectalgenomicmultidisciplinaryscreening

Identifiers

PMID37686649
PMCPMC10487247

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.