Evidence map›Paper›PMID 37686592›Full record

ArticleCancers2023

Environmental and Lifestyle Cancer Risk Factors: Shaping Extracellular Vesicle OncomiRs and Paving the Path to Cancer Development.

Valentina Bollati, Paola Monti, Davide Biganzoli, Giuseppe Marano, Chiara Favero, Simona Iodice, Luca Ferrari, Laura Dioni, Francesca Bianchi, Angela Cecilia Pesatori and 1 more

Abstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Extracellular Vesicle Preparation and Analysis: A State-of-the-Art Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  2. Article
  3. MicroRNAs and Nonalcoholic Steatohepatitis: A Review.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Valentina BollatiEpiget Lab, Department of Clinical Sciences and Community Health, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-0370-9598
Paola MontiEpiget Lab, Department of Clinical Sciences and Community Health, University of Milan, 20133 Milan, Italy.ORCID 0000-0001-8185-497X
Davide BiganzoliCenter of Functional Genomics and Rare Diseases, Buzzi Children's Hospital, 20154 Milan, Italy.ORCID 0000-0002-6509-6870
Giuseppe MaranoUnit of Medical Statistics, Bioinformatics and Epidemiology, Department of Biomedical and Clinical Sciences (DIBIC), University of Milan, 20133 Milan, Italy.
Chiara FaveroEpiget Lab, Department of Clinical Sciences and Community Health, University of Milan, 20133 Milan, Italy.
Simona IodiceEpiget Lab, Department of Clinical Sciences and Community Health, University of Milan, 20133 Milan, Italy.ORCID 0000-0001-5594-8761
Luca FerrariEpiget Lab, Department of Clinical Sciences and Community Health, University of Milan, 20133 Milan, Italy.ORCID 0000-0003-0103-2170
Laura DioniEpiget Lab, Department of Clinical Sciences and Community Health, University of Milan, 20133 Milan, Italy.
Francesca BianchiDipartimento di Scienze Biomediche per la Salute, University of Milan, 20133 Milan, Italy.
Angela Cecilia PesatoriEpiget Lab, Department of Clinical Sciences and Community Health, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-0261-3252
Elia Mario BiganzoliUnit of Medical Statistics, Bioinformatics and Epidemiology, Department of Biomedical and Clinical Sciences (DIBIC), University of Milan, 20133 Milan, Italy.ORCID 0000-0003-1202-5873

Funding

European Research Council ERC-2011-StG 282,413
6 · The paper itself

Abstract

Intercellular communication has been transformed by the discovery of extracellular vesicles (EVs) and their cargo, including microRNAs (miRNAs), which play crucial roles in intercellular signaling. These EVs were previously disregarded as cellular debris but are now recognized as vital mediators of biological information transfer between cells. Furthermore, they respond not only to internal stimuli but also to environmental and lifestyle factors. Identifying EV-borne oncomiRs, a subset of miRNAs implicated in cancer development, could revolutionize our understanding of how environmental and lifestyle exposures contribute to oncogenesis. To investigate this, we studied the plasma levels of EV-borne oncomiRs in a population of 673 women and 238 men with a body mass index > 25 kg/m

Indexed as

environmental exposuresexposomelifestyle factorsMARS modelsoncomiRSPHERE population

Identifiers

PMID37686592
PMCPMC10486808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.