Evidence map›Paper›PMID 37686584›Full record

ReviewCancers2023

The Development of Immunotherapy for the Treatment of Recurrent Glioblastoma.

Xudong Liu, Zihui Zhao, Wufei Dai, Kuo Liao, Qi Sun, Dongjiang Chen, Xingxin Pan, Lishuang Feng, Ying Ding, Shiyou Wei

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Glioblastoma Therapy: Past, Present and Future.International journal of molecular sciences · 2024
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Xudong LiuCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.ORCID 0000-0002-9592-8367
Zihui ZhaoSchool of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.
Wufei DaiDepartment of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering Research, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.
Kuo LiaoSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.ORCID 0009-0008-2473-6131
Qi SunSchool of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Dongjiang ChenDivision of Neuro-Oncology, USC Keck Brain Tumor Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA.ORCID 0000-0003-4611-3898
Xingxin PanDepartment of Oncology, Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.
Lishuang FengSchool of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Ying DingCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Shiyou WeiDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Shanghai Jiao Tong University · CNUniversity of Chinese Academy of Sciences · CNUniversity of Hong Kong · HKLivestrong Foundation · USSichuan University · CNSouth China University of Technology · CNUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrent glioblastoma (rGBM) is a highly aggressive form of brain cancer that poses a significant challenge for treatment in neuro-oncology, and the survival status of patients after relapse usually means rapid deterioration, thus becoming the leading cause of death among patients. In recent years, immunotherapy has emerged as a promising strategy for the treatment of recurrent glioblastoma by stimulating the body's immune system to recognize and attack cancer cells, which could be used in combination with other treatments such as surgery, radiation, and chemotherapy to improve outcomes for patients with recurrent glioblastoma. This therapy combines several key methods such as the use of monoclonal antibodies, chimeric antigen receptor T cell (CAR-T) therapy, checkpoint inhibitors, oncolytic viral therapy cancer vaccines, and combination strategies. In this review, we mainly document the latest immunotherapies for the treatment of glioblastoma and especially focus on rGBM.

Indexed as

cancer vaccineCAR-T therapyimmune checkpoint inhibitorimmunotherapyoncolytic viral therapyrecurrent glioblastoma

Identifiers

PMID37686584
PMCPMC10486426
OpenAlexW4386255830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.