Evidence map›Paper›PMID 37686581›Full record

ArticleCancers2023

Cancer and Pregnancy: Estimates in Italy from Record-Linkage Procedures between Cancer Registries and the Hospital Discharge Database.

Daniela Pierannunzio, Alice Maraschini, Tania Lopez, Serena Donati, Rosalba Amodio, Fortunato Bianconi, Rossella Bruni, Marine Castaing, Claudia Cirilli, Giovanna Fantaci and 18 more

Abstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Subsequent pregnancies after a diagnosis of pregnancy-associated cancer.Acta obstetricia et gynecologica Scandinavica · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Gastric cancer in pregnancy: a review.Future oncology (London, England) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Daniela PierannunzioNational Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, 00162 Rome, Italy.ORCID 0000-0003-3593-9774
Alice MaraschiniTechnical-Scientific Statistical Service, Italian National Institute of Health, 00162 Rome, Italy.ORCID 0000-0003-4754-5385
Tania LopezNational Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, 00162 Rome, Italy.ORCID 0000-0002-6168-400X
Serena DonatiNational Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, 00162 Rome, Italy.ORCID 0000-0002-4607-2072
Rosalba AmodioClinical Epidemiology and Cancer Registry Unit, Azienda Ospedaliera Universitaria Policlinico (AOUP), 90127 Palermo, Italy.
Fortunato BianconiArea Operativa ICT-PuntoZero Scarl, 06128 Perugia, Italy.ORCID 0000-0002-3132-0061
Rossella BruniAReSS Puglia, 70121 Bari, Italy.ORCID 0009-0007-2129-3921
Marine CastaingSiracusa Cancer Registry, Health Unit of Siracusa, 96100 Siracusa, Italy.
Claudia CirilliDipartimento di Epidemiologia e Comunicazione del Rischio, AUSL di Modena, 41126 Modena, Italy.
Giovanna FantaciUOS Registro Tumori ASP Trapani, 91100 Trapani, Italy.
Linda GuardaSC Osservatorio Epidemiologico ATS Valpadana, 46100 Mantova, Italy.
Silvia IacovacciRT LT, Dipartimento di Prevenzione ASL Latina, 04100 Latina, Italy.
Lucia MangoneEuropean Epidemiology Unit, Gynecologic Oncology Department, AUSL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.ORCID 0000-0002-5089-5178
Guido MazzoleniTumor Register South Tyrol, 39100 Bolzano, Italy.ORCID 0000-0002-7498-2428
Walter MazzuccoClinical Epidemiology and Cancer Registry Unit, Azienda Ospedaliera Universitaria Policlinico (AOUP), 90127 Palermo, Italy.ORCID 0000-0001-5090-1366
Anna MelcarneRegistro Tumori ASL di Lecce, 73100 Lecce, Italy.
Elisabetta MerloUOC Epidemiologia, Agenzia per la Tutela della Salute (ATS) della Brianza, 20900 Monza, Italy.
Fabio ParazziniDipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, 20122 Milano, Italy.
Fedro Alessandro PeccatoriGynecologic Oncology Department, European Institute of Oncology IRCCS, 20141 Milan, Italy.ORCID 0000-0001-8227-8740
Massimo RuggeSurgical Pathology & Cytopathology Unit, Department of Medicine (DIMED), University of Padova, 35128 Padova, Italy.
Giuseppe SampietroHealth Protection Agency of Bergamo (ATS Bergamo), 24121 Bergamo, Italy.
Giovanni ScambiaFondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica Roma, 00168 Roma, Italy.
Giovanna ScarfoneGynecologic Oncology Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy.ORCID 0000-0001-9838-9998
Ausilia SferrazzaASP Ragusa-Dipartimento Medico di Prevenzione, UOSD Registro Tumori, 97100 Ragusa, Italy.
Fabrizio StracciAssociazione Nazionale dei Registri Tumori-AIRTUM-Public Health Section, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.
Antonina TorrisiRegistro Tumori Integrato, Azienda Ospedaliero Universitaria Policlinico "G. Rodolico-San Marco", 95123 Catania, Italy.
Maria Francesca VitaleNapoli 3 Sud Cancer Registry, 80031 Brusciano, Italy.
Silvia FrancisciNational Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, 00162 Rome, Italy.ORCID 0000-0002-1552-1744

Funding

Istituto Superiore di Sanità project code ISS20-a4627f16ba39
6 · The paper itself

Abstract

The aim of this study is to describe the frequency and trend of pregnancy-associated cancer (PAC) in Italy, an increasingly relevant phenomenon due to postponing age at childbirth. To this purpose, a population-based retrospective longitudinal study design based on cohorts of women aged 15-49 diagnosed with cancer and concomitant pregnancy is proposed. The study uses 19 population-based Cancer Registries, covering about 22% of Italy, and linked at an individual level with Hospital Discharge Records. A total of 2,861,437 pregnancies and 3559 PAC are identified from 74,165 women of the cohort with a rate of 1.24 PAC per 1000 pregnancies. The most frequent cancer site is breast (24.3%), followed by thyroid (23.9%) and melanoma (14.3%). The most frequent outcome is delivery (53.1%), followed by voluntary termination of pregnancy and spontaneous abortion (both 12.0%). The trend of PAC increased from 2003 to 2015, especially when the outcome is delivery, thus confirming a new attitude of clinicians to manage cancer throughout pregnancy. This represents the first attempt in Italy to describe PAC from Cancer Registries data; the methodology is applicable to other areas with the same data availability. Evidence from this study is addressed to clinicians for improving clinical management of women with PAC.

Indexed as

cancercancer registry recordschildbearing agecohort studyhospital discharge datapopulation-based datapregnancypregnancy outcomerecord linkagereproductive health

Identifiers

PMID37686581
PMCPMC10486505

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.