ReviewCancers2023
A Systematic Review of LET-Guided Treatment Plan Optimisation in Proton Therapy: Identifying the Current State and Future Needs.
Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Particle Arc Therapy in Cancer Radiotherapy: A Scoping Review of Feasibility and Dosimetric Evidence.Cancers · 2026Review
- Mid-range arc therapy for efficient and RBE-robust proton treatment.Physics in medicine and biology · 2026Article
- Deep learning for dose-averaged linear energy transfer estimation in pencil-beam scanning and double scattering proton radiotherapy plans with uncertainty-aware external validation.Physics and imaging in radiation oncology · 2026Article
- MRI and PET Alterations in Adult Skull Base Tumors: A Narrative Review of Proton Versus Photon Radiotherapy.Diagnostics (Basel, Switzerland) · 2026Review
- Enable preclinical, high-precision image-guided radiotherapy research with a stand-alone small animal IGRT system.Medical physics · 2026Article
- A Monte Carlo study of proton LET calculations: Comparison between the codes PENHAN, FLUKA, and TOPAS.Medical physics · 2026Article
- Predicting DNA damage yields and assessing beam quality for protons and carbon ions using a DBSCAN algorithm.Scientific reports · 2026Article
- Commissioning of a Monte Carlo-based scanning proton beam for breast cancer: Incorporating LETd calculations and variable RBE models.Journal of applied clinical medical physics · 2026Article
- A refined approach to compute nanodosimetric quantities for proton and ion radiotherapy treatment planning.Physics in medicine and biology · 2025Article
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- Article
- Immediate 2-Stage breast reconstruction outcomes after proton or photon postmastectomy radiotherapy.Clinical and translational radiation oncology · 2025Article
- LET measurements in proton and helium-ion beams of therapeutic energies using a silicon pixel detector towards a tool for quality assurance.Medical physics · 2025Article
- A review of proton beam therapy's role in glioma management.Medicine · 2025Review
- Efficient proton transport modelling for proton beam therapy and biological quantification.Journal of mathematical biology · 2025Article
- Transmission beam planning for improved robustness and efficiency in proton therapy for head and neck cancer.Physics and imaging in radiation oncology · 2025Article
- Robust Optimization for Spot-Scanning Proton Therapy based on Dose-Linear-Energy-Transfer Volume Constraints.International journal of radiation oncology, biology, physics · 2025Article
- 'Dirty dose'-based proton variable RBE models - performance assessment on in vitro data.Medical physics · 2025Article
- Beyond a constant proton relative biological effectiveness: A survey of clinical and research perspectives among proton institutions in Europe and the United States.Journal of applied clinical medical physics · 2025Article
- Recommendations for reporting and evaluating proton therapy beyond dose and constant relative biological effectiveness.Physics and imaging in radiation oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The well-known clinical benefits of proton therapy are achieved through higher target-conformality and normal tissue sparing than conventional radiotherapy. However, there is an increased sensitivity to uncertainties in patient motion/setup, proton range and radiobiological effect. Although recent efforts have mitigated some uncertainties, radiobiological effect remains unresolved due to a lack of clinical data for relevant endpoints. Therefore, RBE optimisations may be currently unsuitable for clinical treatment planning. LET optimisation is a novel method that substitutes RBE with LET, shifting LET hotspots outside critical structures. This review outlines the current status of LET optimisation in proton therapy, highlighting knowledge gaps and possible future research. Following the PRISMA 2020 guidelines, a search of the MEDLINE® and Scopus databases was performed in July 2023, identifying 70 relevant articles. Generally, LET optimisation methods achieved their treatment objectives; however, clinical benefit is patient-dependent. Inconsistencies in the reported data suggest further testing is required to identify therapeutically favourable methods. We discuss the methods which are suitable for near-future clinical deployment, with fast computation times and compatibility with existing treatment protocols. Although there is some clinical evidence of a correlation between high LET and adverse effects, further developments are needed to inform future patient selection protocols for widespread application of LET optimisation in proton therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.