Evidence map›Paper›PMID 37686538›Full record

ArticleCancers2023

Investigations Using Albumin Binders to Modify the Tissue Distribution Profile of Radiopharmaceuticals Exemplified with Folate Radioconjugates.

Sarah D Busslinger, Anna E Becker, Christian Vaccarin, Luisa M Deberle, Marie-Luise Renz, Viola Groehn, Roger Schibli, Cristina Müller

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Development of Novel Integrin αACS medicinal chemistry letters · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. RadiolabeledFrontiers in nuclear medicine · 2025
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sarah D BusslingerCenter for Radiopharmaceutical Sciences ETH-PSI, Paul Scherrer Institute, Forschungsstrasse 111, 5232 Villigen-PSI, Switzerland.
Anna E BeckerCenter for Radiopharmaceutical Sciences ETH-PSI, Paul Scherrer Institute, Forschungsstrasse 111, 5232 Villigen-PSI, Switzerland.
Christian VaccarinCenter for Radiopharmaceutical Sciences ETH-PSI, Paul Scherrer Institute, Forschungsstrasse 111, 5232 Villigen-PSI, Switzerland.
Luisa M DeberleCenter for Radiopharmaceutical Sciences ETH-PSI, Paul Scherrer Institute, Forschungsstrasse 111, 5232 Villigen-PSI, Switzerland.
Marie-Luise RenzMerck & Cie KmG, Im Laternenacker 5, 8200 Schaffhausen, Switzerland.
Viola GroehnMerck & Cie KmG, Im Laternenacker 5, 8200 Schaffhausen, Switzerland.
Roger SchibliCenter for Radiopharmaceutical Sciences ETH-PSI, Paul Scherrer Institute, Forschungsstrasse 111, 5232 Villigen-PSI, Switzerland.ORCID 0000-0002-1537-3833
Cristina MüllerCenter for Radiopharmaceutical Sciences ETH-PSI, Paul Scherrer Institute, Forschungsstrasse 111, 5232 Villigen-PSI, Switzerland.ORCID 0000-0001-9357-9688
Paul Scherrer Institute · CHMerck Serono (Switzerland) · CH

Funding

Swiss National Science Foundation 310030_188978
6 · The paper itself

Abstract

Introducing an albumin-binding entity into otherwise short-lived radiopharmaceuticals can be an effective means to improve their pharmacokinetic properties due to enhanced blood residence time. In the current study, DOTA-derivatized albumin binders based on 4-(

Indexed as

4-(p-iodophenyl)butanoic acid5-methyltetrahydrofolate5-(p-iodophenyl)pentanoic acidalbumin binderfolate radioconjugatefolate receptorKB tumor cells

Identifiers

PMID37686538
PMCPMC10486429
OpenAlexW4386168308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.