Evidence map›Paper›PMID 37686512›Full record

ReviewCancers2023

Polybrominated Diphenyl Ethers (PBDEs) and Human Health: Effects on Metabolism, Diabetes and Cancer.

Valerio Renzelli, Marco Gallo, Lelio Morviducci, Giampiero Marino, Alberto Ragni, Enzo Tuveri, Antongiulio Faggiano, Rossella Mazzilli, Annalisa Natalicchio, Maria Chiara Zatelli and 17 more

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
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  4. Genomic Impacts of Biological Exposures.Journal of developmental biology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 18 institutions in 1 country.

Valerio RenzelliItalian Association of Clinical Diabetologists, 00192 Rome, Italy.
Marco GalloEndocrinology and Metabolic Diseases Unit, AO SS Antonio e Biagio e Cesare Arrigo of Alessandria, 15121 Alessandria, Italy.ORCID 0000-0001-7166-0848
Lelio MorviducciDiabetology and Nutrition Unit, Department of Medical Specialities, ASL Roma 1, S. Spirito Hospital, 00193 Rome, Italy.
Giampiero MarinoInternal Medicine Department, Ospedale dei Castelli, Asl Roma 6, 00040 Ariccia, Italy.
Alberto RagniEndocrinology and Metabolic Diseases Unit, AO SS Antonio e Biagio e Cesare Arrigo of Alessandria, 15121 Alessandria, Italy.
Enzo TuveriDiabetology, Endocrinology and Metabolic Diseases Service, ASL-Sulcis, 09016 Iglesias, Italy.
Antongiulio FaggianoEndocrinology Unit, Department of Clinical & Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0000-0002-9324-3946
Rossella MazzilliEndocrinology Unit, Department of Clinical & Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy.
Annalisa NatalicchioDepartment of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, 70121 Bari, Italy.ORCID 0000-0002-6131-7517
Maria Chiara ZatelliSection of Endocrinology, Geriatrics and Internal Medicine, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0001-8408-7796
Monica MontagnaniDepartment of Precision and Regenerative Medicine and Ionian Area, Section of Pharmacology, University of Bari Aldo Moro, 70121 Bari, Italy.ORCID 0000-0002-5697-8185
Stefano FogliClinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Dario GiuffridaDepartment of Oncology, Istituto Oncologico del Mediterraneo, Viagrande, 95029 Catania, Italy.ORCID 0000-0001-6404-2304
Antonella ArgentieroMedical Oncology Unit, IRCCS Istituto Tumori "Giovanni Paolo II", 70124 Bari, Italy.
Romano DanesiClinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-4414-8934
Stella D'OronzoInterdisciplinary Department of Medicine, University of Bari Aldo Moro, 70121 Bari, Italy.ORCID 0000-0002-1071-2058
Stefania GoriOncologia Medica, IRCCS Ospedale Don Calabria-Sacro Cuore di Negrar, 37024 Verona, Italy.ORCID 0000-0001-6320-405X
Tindara FranchinaMedical Oncology Unit, Department of Human Pathology "G. Barresi", University of Messina, 98122 Messina, Italy.ORCID 0000-0001-5920-4997
Antonio RussoDepartment of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, 90133 Palermo, Italy.
Matteo MonamiDiabetology, Careggi University Hospital, University of Florence, 50134 Florence, Italy.ORCID 0000-0001-9349-828X
Laura SciaccaDepartment of Clinical and Experimental Medicine, Endocrinology Section, University of Catania, 95124 Catania, Italy.ORCID 0000-0002-3258-7200
Saverio CinieriMedical Oncology Division, Breast Unit, Senatore Antonio Perrino Hospital, ASL Brindisi, 72100 Brindisi, Italy.
Annamaria ColaoEndocrinology, Diabetology and Andrology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, 80138 Naples, Italy.
Angelo AvogaroDepartment of Medicine, Section of Diabetes and Metabolic Diseases, University of Padova, 35122 Padova, Italy.
Graziano Di CianniDiabetes Unit, Livorno Hospital, 57100 Livorno, Italy.
Francesco GiorginoDepartment of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, 70121 Bari, Italy.ORCID 0000-0001-7372-2678
Nicola SilvestrisMedical Oncology Unit, Department of Human Pathology "G. Barresi", University of Messina, 98122 Messina, Italy.
University of Bari Aldo Moro · ITAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo · ITSapienza University of Rome · ITUniversity of Messina · ITUniversity of Pisa · ITASL Roma · ITCittà di Castello Hospital · ITFederico II University Hospital · ITIstituto Oncologico Veneto · ITIstituto Tumori Bari · ITOspedale A. Perrino · ITOspedale di Livorno · ITOspedale Sacro Cuore Don Calabria · ITUniversity of Catania · ITUniversity of Ferrara · ITUniversity of Florence · ITUniversity of Padua · ITUniversity of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is increasing evidence of the role of endocrine disruptors (EDs) derived from commonly employed compounds for manufacturing and processing in altering hormonal signaling and function. Due to their prolonged half-life and persistence, EDs can usually be found not only in industrial products but also in households and in the environment, creating the premises for long-lasting exposure. Polybrominated diphenyl ethers (PBDEs) are common EDs used in industrial products such as flame retardants, and recent studies are increasingly showing that they may interfere with both metabolic and oncogenic pathways. In this article, a multidisciplinary panel of experts of the Italian Association of Medical Diabetologists (AMD), the Italian Society of Diabetology (SID), the Italian Association of Medical Oncology (AIOM), the Italian Society of Endocrinology (SIE) and the Italian Society of Pharmacology (SIF) provides a review on the potential role of PBDEs in human health and disease, exploring both molecular and clinical aspects and focusing on metabolic and oncogenic pathways.

Indexed as

cancerdiabetesendocrine disruptorsenvironmentmetabolismobesityPBDE

Identifiers

PMID37686512
PMCPMC10486428
OpenAlexW4386119742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.