Evidence map›Paper›PMID 37686468›Full record

ArticleInternational journal of molecular sciences2023

FoxO3 Modulates Circadian Rhythms in Neural Stem Cells.

Swip Draijer, Raissa Timmerman, Jesse Pannekeet, Alexandra van Harten, Elham Aida Farshadi, Julius Kemmer, Demy van Gilst, Inês Chaves, Marco F M Hoekman

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Swip DraijerSwammerdam Institute of Life Sciences, University of Amsterdam, 1018 WB Amsterdam, The Netherlands.
Raissa TimmermanSwammerdam Institute of Life Sciences, University of Amsterdam, 1018 WB Amsterdam, The Netherlands.
Jesse PannekeetSwammerdam Institute of Life Sciences, University of Amsterdam, 1018 WB Amsterdam, The Netherlands.
Alexandra van HartenSwammerdam Institute of Life Sciences, University of Amsterdam, 1018 WB Amsterdam, The Netherlands.
Elham Aida FarshadiDepartment of Molecular Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
Julius KemmerDepartment of Molecular Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
Demy van GilstDepartment of Molecular Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
Inês ChavesDepartment of Molecular Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0001-6494-0008
Marco F M HoekmanSwammerdam Institute of Life Sciences, University of Amsterdam, 1018 WB Amsterdam, The Netherlands.
University of Amsterdam · NLErasmus MC · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Both FoxO transcription factors and the circadian clock act on the interface of metabolism and cell cycle regulation and are important regulators of cellular stress and stem cell homeostasis. Importantly, FoxO3 preserves the adult neural stem cell population by regulating cell cycle and cellular metabolism and has been shown to regulate circadian rhythms in the liver. However, whether FoxO3 is a regulator of circadian rhythms in neural stem cells remains unknown. Here, we show that loss of FoxO3 disrupts circadian rhythmicity in cultures of neural stem cells, an effect that is mediated via regulation of

Indexed as

Circadian ClocksCircadian RhythmForkhead Box Protein O3Neural Stem CellsAnimalsCell CycleCell DivisionMiceForkhead Box Protein O3FoxO3 protein, mousecell cyclecircadian rhythmsFoxO3livermetabolismneural stem cell

Identifiers

PMID37686468
PMCPMC10563086
OpenAlexW4386422563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.