Evidence map›Paper›PMID 37686458›Full record

ArticleInternational journal of molecular sciences2023

Pharmacological Inhibition and Genetic Deletion of Cystathionine Gamma-Lyase in Mice Protects against Organ Injury in Sepsis: A Key Role of Adhesion Molecules on Endothelial Cells.

Sumeet Manandhar, Stephen Chambers, Andrew Miller, Isao Ishii, Madhav Bhatia

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Sumeet ManandharDepartment of Pathology and Biomedical Science, University of Otago, Christchurch 8140, New Zealand.ORCID 0000-0002-5593-7357
Stephen ChambersDepartment of Pathology and Biomedical Science, University of Otago, Christchurch 8140, New Zealand.
Andrew MillerDepartment of Pathology and Biomedical Science, University of Otago, Christchurch 8140, New Zealand.
Isao IshiiDepartment of Health Chemistry, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan.ORCID 0000-0002-5367-205X
Madhav BhatiaDepartment of Pathology and Biomedical Science, University of Otago, Christchurch 8140, New Zealand.
University of Otago · NZShowa Pharmaceutical University · JP

Funding

Japan Society for the Promotion of Science 22H05577Maurice and Phyllis Paykel TrustUniversity of Otago
6 · The paper itself

Abstract

Hydrogen sulfide (H

Indexed as

Cystathionine gamma-LyaseSepsisAnimalsCell Adhesion MoleculesEndothelial CellsGene DeletionMiceNF-kappa BCell Adhesion MoleculesCystathionine gamma-LyaseNF-kappa Badhesion moleculescystathionine gamma-lyaseendothelial cellshydrogen sulfidesepsis

Identifiers

PMID37686458
PMCPMC10487872
OpenAlexW4386422685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.