Evidence map›Paper›PMID 37686414›Full record

ArticleInternational journal of molecular sciences2023

Effect of Repeated Bolus and Continuous Glucose Infusion on DNA Damage and Oxidative Stress Biomarkers in Healthy Male Volunteers.

Laura Bragagna, Christina Polak, Lisa Schütz, Lina Maqboul, Carmen Klammer, Roland Feldbauer, Agnes Draxler, Martin Clodi, Karl-Heinz Wagner

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laura BragagnaDepartment of Nutritional Sciences, University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-8676-3863
Christina PolakDepartment of Nutritional Sciences, University of Vienna, 1090 Vienna, Austria.
Lisa SchützDepartment of Nutritional Sciences, University of Vienna, 1090 Vienna, Austria.
Lina MaqboulDepartment of Nutritional Sciences, University of Vienna, 1090 Vienna, Austria.ORCID 0009-0000-6080-886X
Carmen KlammerVienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, 1090 Vienna, Austria.
Roland FeldbauerDepartment of Internal Medicine, St. John of God Hospital Linz, 4020 Linz, Austria.
Agnes DraxlerDepartment of Nutritional Sciences, University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-9750-4149
Martin ClodiDepartment of Internal Medicine, St. John of God Hospital Linz, 4020 Linz, Austria.
Karl-Heinz WagnerDepartment of Nutritional Sciences, University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-1683-7265

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucose variability (GV), which describes fluctuations in blood glucose levels within the day, is a phenomenon that is increasingly becoming the target of scientific attention when it comes to increased risk of coronary heart disease. Effects of GV may contribute to the development of metabolic syndrome and type 2 diabetes. Hyperglycemia can lead to oxidative stress resulting in molecular damage due to accumulation of reactive oxygen species (ROS). To discover more about the immediate effects of GV, continuous vs. bolus intravenous glucose administration was applied to 10 healthy men aged 21-30 years over a time frame of 48 h. Whole blood and plasma were analyzed for DNA damage using a comet assay with 3 different treatments (lysis buffer, H

Indexed as

Diabetes Mellitus, Type 2GlucoseBilirubinBiomarkersDNA DamageHumansHydrogen PeroxideMaleOxidative StressVolunteersBilirubinBiomarkersGlucoseHydrogen Peroxideantioxidantsbilirubincomet assayDNA damageglucoseglucose variabilityhyperglycemiaoxidative stressprotein carbonylsROStype 2 diabetes

Identifiers

PMID37686414
PMCPMC10487933

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.