Evidence map›Paper›PMID 37686350›Full record

Observational studyInternational journal of molecular sciences2023

Mucins 3A and 3B Are Expressed in the Epithelium of Human Large Airway.

Heta Merikallio, Terezia Pincikova, Ioanna Kotortsi, Reza Karimi, Chuan-Xing Li, Helena Forsslund, Mikael Mikko, Sven Nyrén, Elisa Lappi-Blanco, Åsa M Wheelock and 2 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Heta MerikallioResearch Unit of Biomedicine and Internal Medicine, University of Oulu, 90570 Oulu, Finland.ORCID 0000-0002-0967-3987
Terezia PincikovaRespiratory Medicine Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.
Ioanna KotortsiRespiratory Medicine Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0003-0531-5338
Reza KarimiRespiratory Medicine Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.
Chuan-Xing LiRespiratory Medicine Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.
Helena ForsslundRespiratory Medicine Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.
Mikael MikkoRespiratory Medicine Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.
Sven NyrénDepartment of Molecular Medicine and Surgery, Division of Radiology, Karolinska Institutet, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden.
Elisa Lappi-BlancoCancer and Translational Medicine Research Unit, Department of Pathology, University Hospital of Oulu, Oulu University, 90220 Oulu, Finland.
Åsa M WheelockRespiratory Medicine Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.
Riitta KaarteenahoResearch Unit of Biomedicine and Internal Medicine, University of Oulu, 90570 Oulu, Finland.
Magnus C SköldRespiratory Medicine Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.
Karolinska University Hospital · SEKarolinska Institutet · SEOulu University Hospital · FI

Funding

a state subsidy of Oulu University HospitalERS-EU RESPIRE2 MCF [7214]-2013Jalmari and Rauha Ahokas FoundationKarolinska InstitutetKing Gustaf V's and Queen Victoria's Freemasons' FoundationRegional Agreement on Medical Training and Clinical Research (ALF) between Stockholm County Council and Karolinska InstitutetResearch Foundation of the Pulmonary DiseasesSwedish Heart-Lung FoundationThe Swedish Research Council 2018-00520
6 · The paper itself

Abstract

Aberrant mucus secretion is a hallmark of chronic obstructive pulmonary disease (COPD). Expression of the membrane-tethered mucins 3A and 3B (MUC3A, MUC3B) in human lung is largely unknown. In this observational cross-sectional study, we recruited subjects 45-65 years old from the general population of Stockholm, Sweden, during the years 2007-2011. Bronchial mucosal biopsies, bronchial brushings, and bronchoalveolar lavage fluid (BALF) were retrieved from COPD patients (n = 38), healthy never-smokers (n = 40), and smokers with normal lung function (n = 40). Protein expression of MUC3A and MUC3B in bronchial mucosal biopsies was assessed by immunohistochemical staining. In a subgroup of subjects (n = 28), MUC3A and MUC3B mRNAs were quantified in bronchial brushings using microarray. Non-parametric tests were used to perform correlation and group comparison analyses. A value of

Indexed as

EmphysemaPulmonary Disease, Chronic ObstructiveAgedEpitheliumHumansMaleMiddle AgedMucinsThoraxMucinsbronchoalveolar lavageCOPDepitheliumimmunohistochemistrylarge airwayslung functionmicroarraymRNAmucinsmoking

Identifiers

PMID37686350
PMCPMC10487631
OpenAlexW4386308377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.