Evidence map›Paper›PMID 37686279›Full record

ArticleInternational journal of molecular sciences2023

Blood Proteome Profiling Reveals Biomarkers and Pathway Alterations in Fragile X PM at Risk for Developing FXTAS.

Marwa Zafarullah, Jie Li, Michelle R Salemi, Brett S Phinney, Blythe P Durbin-Johnson, Randi Hagerman, David Hessl, Susan M Rivera, Flora Tassone

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06957054 (Assessment of Neural Biomarkers in Adult Subjects With Fragile X Syndrome and Typically Developing Subjects), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06957054 completednot on this mapstarted 2024, after this paper: background citation

Assessment of Neural Biomarkers in Adult Subjects With Fragile X Syndrome and Typically Developing Subjects

TypeobservationalSponsorConnecta Therapeutics, S.L.Ran2024 to 2025Enrolled20ConditionsFragile X Syndrome (FXS), Neurotypical AdultsArmsAny
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. In Utero Alcohol and Unsuitable Home Environmental Exposure Combined withInternational journal of molecular sciences · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Marwa ZafarullahDepartment of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.ORCID 0000-0003-1856-0535
Jie LiGenome Center, Bioinformatics Core, University of California Davis, Davis, CA 95616, USA.
Michelle R SalemiGenome Center, Proteomics Core, Genome and Biomedical Sciences Facility, University of California Davis, Davis, CA 95616, USA.
Brett S PhinneyGenome Center, Proteomics Core, Genome and Biomedical Sciences Facility, University of California Davis, Davis, CA 95616, USA.ORCID 0000-0003-3870-3302
Blythe P Durbin-JohnsonDivision of Biostatistics, School of Medicine, University of California Davis, Davis, CA 95616, USA.
Randi HagermanMIND Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA.ORCID 0000-0001-5029-8448
David HesslMIND Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA.
Susan M RiveraMIND Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA.ORCID 0000-0002-4870-4774
Flora TassoneDepartment of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.ORCID 0000-0002-6388-9180
University of California, Davis · USUniversity of California Davis Medical Center · US

Funding

Trajectories and Markers of Neurodegeneration in Fragile X Premutation CarriersR01MH078041 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HESSL, DAVID R, RIVERA, SUSAN M · 2007 to 2017
$5.4M
Trajectories and Markers of Neurodegeneration in Fragile X Premutation CarriersR01NS110100 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DAVID R HESSL, Susan M Rivera · 2018 to 2026
$5.4M
QE-HF-X Mass SpectrometerS10OD026918 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PHINNEY, BRETT S · 2020 to 2020
$600k
NIH HHS S10 OD026918NIMH NIH HHS R01 MH078041NINDS NIH HHS R01 NS110100
6 · The paper itself

Abstract

Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) is a neurodegenerative disorder associated with the

Indexed as

ProteomeProteomicsAtaxiaBiomarkersChromatography, LiquidFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeHumansLongitudinal StudiesTandem Mass SpectrometryTremorBiomarkersFMR1 protein, humanFragile X Messenger Ribonucleoprotein 1Proteomebiomarkerblood proteomicfragile X-associated tremor/ataxia syndromeFXTASpathwayspremutationprotein alterations

Identifiers

PMID37686279
PMCPMC10488017
OpenAlexW4386284174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.