Evidence map›Paper›PMID 37686236›Full record

ArticleInternational journal of molecular sciences2023

Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson's Disease.

Viviana Brembati, Gaia Faustini, Francesca Longhena, Tiago Fleming Outeiro, Arianna Bellucci

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. The Progress of Active Immunotherapy for Parkinson's Disease.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Viviana BrembatiDepartment of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.
Gaia FaustiniDepartment of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.ORCID 0000-0002-0751-3082
Francesca LonghenaDepartment of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.ORCID 0000-0001-6569-9412
Tiago Fleming OuteiroDepartment of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Goettingen, 37073 Goettingen, Germany.ORCID 0000-0003-1679-1727
Arianna BellucciDepartment of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.ORCID 0000-0002-9581-1919
University of Brescia · ITMax Planck Institute for Multidisciplinary Sciences

Funding

Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) EXC 2067/1- 390729940Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) SFB1286 (B8)Michael J. Fox Foundation for Parkinson's Research, NY, USA #10742MIUR PRIN 2017-1065MSA Coalition, USA Testing MPH as a novel neuroprotective therapy in preclinical models of MSA
6 · The paper itself

Abstract

Parkinson's disease (PD) pathology is characterized by the loss of dopaminergic neurons of the nigrostriatal system and accumulation of Lewy bodies (LB) and Lewy neurites (LN), inclusions mainly composed of alpha-synuclein (α-Syn) fibrils. Studies linking the occurrence of mutations and multiplications of the α-Syn gene (

Indexed as

Parkinson Diseasealpha-SynucleinAnimalsDisease Models, AnimalHumansLewy BodiesMicePhosphorylationProtein Processing, Post-Translationalalpha-SynucleinSNCA protein, humanacetylationalpha-synucleinnitrationParkinson’s diseasephosphorylationposttranslational modifications

Identifiers

PMID37686236
PMCPMC10488235
OpenAlexW4386285018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.