Evidence map›Paper›PMID 37686184›Full record

ArticleInternational journal of molecular sciences2023

Potential Association of Cytochrome P450 Copy Number Alteration in Tumour with Chemotherapy Resistance in Lung Adenocarcinoma Patients.

Evelyn Incze, Katalin Mangó, Ferenc Fekete, Ádám Ferenc Kiss, Ádám Póti, Tünde Harkó, Judit Moldvay, Dávid Szüts, Katalin Monostory

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Down-Regulation of CYP3A4 by the KInternational journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Evelyn InczeInstitute of Enzymology, Research Centre for Natural Sciences, Magyar Tudósok 2, H-1117 Budapest, Hungary.
Katalin MangóInstitute of Enzymology, Research Centre for Natural Sciences, Magyar Tudósok 2, H-1117 Budapest, Hungary.
Ferenc FeketeInstitute of Enzymology, Research Centre for Natural Sciences, Magyar Tudósok 2, H-1117 Budapest, Hungary.
Ádám Ferenc KissInstitute of Enzymology, Research Centre for Natural Sciences, Magyar Tudósok 2, H-1117 Budapest, Hungary.
Ádám PótiInstitute of Enzymology, Research Centre for Natural Sciences, Magyar Tudósok 2, H-1117 Budapest, Hungary.
Tünde HarkóDepartment of Pathology, National Korányi Institute of Pulmonology, Pihenő 1, H-1121 Budapest, Hungary.
Judit Moldvay1st Department of Pulmonology, National Korányi Institute of Pulmonology, Pihenő 1, H-1121 Budapest, Hungary.ORCID 0000-0001-9425-1748
Dávid SzütsInstitute of Enzymology, Research Centre for Natural Sciences, Magyar Tudósok 2, H-1117 Budapest, Hungary.ORCID 0000-0001-7985-0136
Katalin MonostoryInstitute of Enzymology, Research Centre for Natural Sciences, Magyar Tudósok 2, H-1117 Budapest, Hungary.ORCID 0000-0002-0861-1450
Institute of Molecular Life Sciences · HUOrszágos Korányi Tbc és Pulmonológiai Intézet · HUSemmelweis University · HU

Funding

ELIXIR ELIXIR HU 2019 HCNVNational Research, Development and Innovation Fund of Hungary 2018-1.2.1-NKP-2018-00005National Research, Development and Innovation Fund of Hungary TKP2021-EGA-31National Research, Development and Innovation Office of Hungary K129065Territorial Development Operational Programs of Prime Minister's Office in Hungary VEKOP 2.3.3 15 2017 00014
6 · The paper itself

Abstract

Resistance to anticancer agents is a major obstacle to efficacious tumour therapy and responsible for high cancer-related mortality rates. Some resistance mechanisms are associated with pharmacokinetic variability in anticancer drug exposure due to genetic polymorphisms of drug-metabolizing cytochrome P450 (CYP) enzymes, whereas variations in tumoural metabolism as a consequence of

Indexed as

AdenocarcinomaAdenocarcinoma of LungCytochrome P-450 Enzyme SystemLung NeoplasmsCytochrome P-450 CYP2C8Cytochrome P-450 CYP3ADNA Copy Number VariationsDrug Resistance, NeoplasmHumansCYP3A4 protein, humanCytochrome P-450 CYP2C8Cytochrome P-450 CYP3ACytochrome P-450 Enzyme Systemcopy number alterationCYP2C8CYP3A4lung adenocarcinomapaclitaxel-metabolizing capacityresistance to anticancer therapy

Identifiers

PMID37686184
PMCPMC10487787
OpenAlexW4386254963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.