Beckwith-Wiedemann Syndrome in Newborn of Mother with HELLP Syndrome/Preeclampsia: An Analysis of Literature and Case Report with Fetal Growth Restriction and Absence of

Jakub Staniczek, Maisa Manasar-Dyrbuś, Agnieszka Drosdzol-Cop, Rafał Stojko

Open access · goldAbstract readCase Reports

In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.9field-weighted citation impact, top 20% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

Special Issue of Pathogenesis of Pregnancy-Related Complications, 2023.International journal of molecular sciences · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jakub StaniczekChair and Department of Gynecology, Obstetrics and Gynecologic Oncology, Medical University of Silesia, 40-211 Katowice, Poland.ORCID 0000-0002-0740-7167

Maisa Manasar-DyrbuśChair and Department of Gynecology, Obstetrics and Gynecologic Oncology, Medical University of Silesia, 40-211 Katowice, Poland.

Agnieszka Drosdzol-CopChair and Department of Gynecology, Obstetrics and Gynecologic Oncology, Medical University of Silesia, 40-211 Katowice, Poland.ORCID 0000-0003-1249-5840

Rafał StojkoChair and Department of Gynecology, Obstetrics and Gynecologic Oncology, Medical University of Silesia, 40-211 Katowice, Poland.ORCID 0000-0002-5141-1016

Medical University of Silesia · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Beckwith-Wiedemann Syndrome (BWS) is an imprinting disorder, which manifests by overgrowth and predisposition to embryonal tumors. The evidence on the relationship between maternal complications such as HELLP (hemolysis, elevated liver enzymes, and low platelet count) and preeclampsia and the development of BWS in offspring is scarce. A comprehensive clinical evaluation, with genetic testing focused on screening for mutations in the CDKN1C gene, which is commonly associated with BWS, was conducted in a newborn diagnosed with BWS born to a mother with a history of preeclampsia and HELLP syndrome. The case study revealed typical clinical manifestations of BWS in the newborn, including hemihyperplasia, macroglossia, midfacial hypoplasia, omphalocele, and hypoglycemia. Surprisingly, the infant also exhibited fetal growth restriction, a finding less commonly observed in BWS cases. Genetic analysis, however, showed no mutations in the

Indexed as

Beckwith-Wiedemann SyndromeHELLP SyndromePre-EclampsiaCyclin-Dependent Kinase Inhibitor p57FemaleFetal Growth RetardationGenetic VariationHumansInfantInfant, NewbornMothersPregnancyCDKN1C protein, humanCyclin-Dependent Kinase Inhibitor p57Beckwith–Wiedemann syndromeCDKN1Cfetal growth restrictionHELLP syndromepreeclampsia

Identifiers

PMID37686168

DOI10.3390/ijms241713360

PMCPMC10487691

OpenAlexW4386254885

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.