Evidence map›Paper›PMID 37686150›Full record

ArticleInternational journal of molecular sciences2023

Forced Hepatic Expression of NRF2 or NQO1 Impedes Hepatocyte Lipid Accumulation in a Lipodystrophy Mouse Model.

Nobunao Wakabayashi, Yoko Yagishita, Tanvi Joshi, Thomas W Kensler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Dual Deletion ofInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nobunao WakabayashiTranslational Research Program, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Yoko YagishitaTranslational Research Program, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
Tanvi JoshiTranslational Research Program, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0009-0001-9251-242X
Thomas W KenslerTranslational Research Program, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0002-6676-261X
Fred Hutch Cancer Center · US

Funding

Targeting Nrf2 for Cancer ChemopreventionR35CA197222 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KENSLER, THOMAS W · 2015 to 2021
$6.7M
NCI NIH HHS R35 CA197222
6 · The paper itself

Abstract

Lipodystrophy is a disorder featuring loss of normal adipose tissue depots due to impaired production of normal adipocytes. It leads to a gain of fat deposition in ectopic tissues such as liver and skeletal muscle that results in steatosis, dyslipidemia, and insulin resistance. Previously, we established a

Indexed as

Fatty LiverLipodystrophyNF-E2-Related Factor 2AnimalsDisease Models, AnimalHepatocytesHepatomegalyKelch-Like ECH-Associated Protein 1LipidsMiceNAD(P)H Dehydrogenase (Quinone)Kelch-Like ECH-Associated Protein 1LipidsNAD(P)H Dehydrogenase (Quinone)NF-E2-Related Factor 2Nqo1 protein, mousehydrodynamic tail vein injectionKEAP1lipodystrophylipogenesisliverNQO1NRF2

Identifiers

PMID37686150
PMCPMC10487640
OpenAlexW4386255186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.