Evidence map›Paper›PMID 37686096›Full record

ArticleInternational journal of molecular sciences2023

Pharmacological Inhibition of NHE1 Protein Increases White Matter Resilience and Neurofunctional Recovery after Ischemic Stroke.

Shamseldin Ayman Hassan Metwally, Satya Siri Paruchuri, Lauren Yu, Okan Capuk, Nicholas Pennock, Dandan Sun, Shanshan Song

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Channels and Transporters in Ischemic Brain Edema.Journal of inflammation research · 2025
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Deletion of Slc9a1 in Cx3cr1Journal of neuroinflammation · 2024
    Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Shamseldin Ayman Hassan MetwallyDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-3819-6665
Satya Siri ParuchuriDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Lauren YuDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Okan CapukDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Nicholas PennockDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Dandan SunDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Shanshan SongDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0002-7200-5922
University of Pittsburgh · US

Funding

The Role of Na+/H+ exchanger in Cerebral IschemiaR01NS048216 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Dandan Sun · 2005 to 2026
$6.1M
BLRD Research Career Scientist Award ApplicationIK6BX005647 · VA · VETERANS HEALTH ADMINISTRATION · PI Dandan Sun · 2021 to 2026
–
BLRD VA I01 BX006372BLRD VA IK6 BX005647NINDS NIH HHS R01 NS048216
6 · The paper itself

Abstract

To date, recanalization interventions are the only available treatments for ischemic stroke patients; however, there are no effective therapies for reducing stroke-induced neuroinflammation. We recently reported that H

Indexed as

Ischemic StrokeSodium-Hydrogen Exchanger 1StrokeWhite MatterAnimalsAnti-Arrhythmia AgentsGuanidinesInflammationMiceMice, Inbred C57BLSulfonesAnti-Arrhythmia AgentscariporideGuanidinesSlc9a1 protein, mouseSodium-Hydrogen Exchanger 1SulfonesCariporideinflammationmicrogliamyelinationRimeporidewhite matter

Identifiers

PMID37686096
PMCPMC10488118
OpenAlexW4386221368

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.