Evidence map›Paper›PMID 37686089›Full record

ArticleInternational journal of molecular sciences2023

Genetic Variation in miR-27a Is Associated with Fluoropyrimidine-Associated Toxicity in Patients with Dihydropyrimidine Dehydrogenase Variants after Genotype-Guided Dose Reduction.

Samantha Medwid, Theodore J Wigle, Cameron Ross, Richard B Kim

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Samantha MedwidDepartment of Medicine, University of Western Ontario, London, ON N6A 3K7, Canada.
Theodore J WigleDepartment of Medicine, University of Western Ontario, London, ON N6A 3K7, Canada.
Cameron RossDepartment of Medicine, University of Western Ontario, London, ON N6A 3K7, Canada.
Richard B KimDepartment of Medicine, University of Western Ontario, London, ON N6A 3K7, Canada.ORCID 0000-0001-8148-1632
Western University · CA

Funding

CIHR PHT-178435
6 · The paper itself

Abstract

Dihydropyrimidine dehydrogenase (

Indexed as

Dihydrouracil Dehydrogenase (NADP)MicroRNAsAntimetabolitesDrug TaperingGenetic VariationGenotypeHumansAntimetabolitesDihydrouracil Dehydrogenase (NADP)MicroRNAs5-fluorouracilDPYDfluoropyrimidinesmiR-27AmiRNApharmacogenomics

Identifiers

PMID37686089
PMCPMC10487873
OpenAlexW4386221465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.