Evidence map›Paper›PMID 37686085›Full record

ArticleInternational journal of molecular sciences2023

Protein Disulfide Isomerase A3 (PDIA3): A Pharmacological Target in Glioblastoma?

Giuliano Paglia, Marco Minacori, Giorgia Meschiari, Sara Fiorini, Silvia Chichiarelli, Margherita Eufemi, Fabio Altieri

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Analysis of Punicalin and Punicalagin Interaction with PDIA3 and PDIA1.International journal of molecular sciences · 2024
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Giuliano PagliaDepartment of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0003-0486-5071
Marco MinacoriDepartment of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0003-4975-0788
Giorgia MeschiariDepartment of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.
Sara FioriniDepartment of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0003-4864-4350
Silvia ChichiarelliDepartment of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0002-5682-0353
Margherita EufemiDepartment of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0001-9153-972X
Fabio AltieriDepartment of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0002-6546-2738
Sapienza University of Rome · IT

Funding

Sapienza University of Rome AR120172B4895C3D to G.P. and RM12117A80A6D512 to M.E.
6 · The paper itself

Abstract

The protein disulfide isomerase A3 (PDIA3) is directly or indirectly involved in various physiopathological processes and participates in cancer initiation, progression and chemosensitivity. However, little is known about its involvement in glioblastoma. To obtain specific information, we performed cellular experiments in the T98G and U-87 MG glioblastoma cell lines to evaluate the role of PDIA3. The loss of PDIA3 functions, either through inhibition or silencing, reduced glioblastoma cells spreading by triggering cytotoxic phenomena. PDIA3 inhibition led to a redistribution of PDIA3, resulting in the formation of protein aggregates visualized through immunofluorescence staining. Concurrently, cell cycle progression underwent arrest at the G

Indexed as

GlioblastomaBiological AssayHumansPhosphorylationProtein Disulfide-IsomerasesTemozolomidePDIA3 protein, humanProtein Disulfide-IsomerasesTemozolomidecancerERp57glioblastomainhibitorPDIA3protein disulfide isomerasepunicalagintemozolomide

Identifiers

PMID37686085
PMCPMC10488224
OpenAlexW4386221393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.