Evidence map›Paper›PMID 37686027›Full record

ArticleInternational journal of molecular sciences2023

Structures of the Insecticidal Toxin Complex Subunit XptA2 Highlight Roles for Flexible Domains.

Cole L Martin, David W Chester, Christopher D Radka, Lurong Pan, Zhengrong Yang, Rachel C Hart, Elad M Binshtein, Zhao Wang, Lisa Nagy, Lawrence J DeLucas and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Evaluating TcAs for Use in Biotechnology Applications.Biotech (Basel (Switzerland)) · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Cole L MartinDepartment of Pharmacology & Toxicology, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
David W ChesterDepartment of Pharmacology & Toxicology, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
Christopher D RadkaDepartment of Pharmacology & Toxicology, University of Alabama at Birmingham, Birmingham, AL 35205, USA.ORCID 0000-0002-6037-7710
Lurong PanDepartment of Pharmacology & Toxicology, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
Zhengrong YangDepartment of Biochemistry & Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
Rachel C HartDepartment of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Elad M BinshteinDepartment of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0003-2745-104X
Zhao WangBiochemistry & Molecular Pharmacology, Cryo-Electron Microscopy and Tomography Core, Baylor College of Medicine, Houston, TX 77030, USA.
Lisa NagyDepartment of Mathematics, Engineering & Physical Sciences, Jefferson State Community College, Jefferson Campus, Birmingham, AL 35215, USA.ORCID 0009-0005-9749-4581
Lawrence J DeLucasPredictive Oncology Inc., 200 Riverhills Business Park, Suite 250, Birmingham, AL 35242, USA.
Stephen G AllerDepartment of Pharmacology & Toxicology, University of Alabama at Birmingham, Birmingham, AL 35205, USA.ORCID 0000-0003-0379-5534
University of Alabama at Birmingham · USVanderbilt University Medical Center · USBaylor College of Medicine · USJefferson State Community College · USUniversity of Kentucky · US

Funding

Bacterial anti-inflammatory lipid mediatorsR00AI166116 · NIAID · UNIVERSITY OF KENTUCKY · PI RADKA, CHRISTOPHER DAVID · 2023 to 2025
$733k
Bacterial anti-inflammatory lipid mediatorsK99AI166116 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI RADKA, CHRISTOPHER DAVID · 2022 to 2023
$147k
NIAID NIH HHS K99 AI166116NIAID NIH HHS R00 AI166116
6 · The paper itself

Abstract

The Toxin Complex (Tc) superfamily consists of toxin translocases that contribute to the targeting, delivery, and cytotoxicity of certain pathogenic Gram-negative bacteria. Membrane receptor targeting is driven by the A-subunit (TcA), which comprises IgG-like receptor binding domains (RBDs) at the surface. To better understand XptA2, an insect specific TcA secreted by the symbiont

Indexed as

InsecticidesToxins, BiologicalBandagesBiological TransportCrystallography, X-RayProtein FoldingInsecticidesToxins, BiologicalCryo-EMTcAtoxin translocaseX-ray crystallography

Identifiers

PMID37686027
PMCPMC10487846
OpenAlexW4386168010

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.