Evidence map›Paper›PMID 37686004›Full record

SynthesisInternational journal of molecular sciences2023

Animal Models for Studying Protein-Bound Uremic Toxin Removal-A Systematic Review.

Sabbir Ahmed, Joost C de Vries, Jingyi Lu, Milan H Verrijn Stuart, Silvia M Mihăilă, Robin W M Vernooij, Rosalinde Masereeuw, Karin G F Gerritsen

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sabbir AhmedDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands.ORCID 0000-0002-0865-6608
Joost C de VriesDepartment of Nephrology and Hypertension, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Jingyi LuDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands.ORCID 0000-0002-0510-5034
Milan H Verrijn StuartDepartment of Nephrology and Hypertension, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Silvia M MihăilăDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands.
Robin W M VernooijDepartment of Nephrology and Hypertension, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Rosalinde MasereeuwDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands.ORCID 0000-0002-1560-1074
Karin G F GerritsenDepartment of Nephrology and Hypertension, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.ORCID 0000-0002-1917-6255
University Medical Center Utrecht · NLUtrecht University · NL

Funding

European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant 813839National Growth Fund program NXTGEN HIGHTECH by the European Commission 101099092
6 · The paper itself

Abstract

Protein-bound uremic toxins (PBUTs) are associated with the progression of chronic kidney disease (CKD) and its associated morbidity and mortality. The conventional dialysis techniques are unable to efficiently remove PBUTs due to their plasma protein binding. Therefore, novel approaches are being developed, but these require validation in animals before clinical trials can begin. We conducted a systematic review to document PBUT concentrations in various models and species. The search strategy returned 1163 results for which abstracts were screened, resulting in 65 full-text papers for data extraction (rats (

Indexed as

Renal InsufficiencyToxins, BiologicalAnimalsCreatinineDogsGoatsHumansIndicanMiceModels, AnimalRatsSwineUremic ToxinsCreatinineIndicanToxins, BiologicalUremic Toxinsanimal modelschronic kidney diseasehippuric acidindoxyl sulfatepara-cresyl sulfateprotein-bound uremic toxins

Identifiers

PMID37686004
PMCPMC10487432
OpenAlexW4386162027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.