Evidence map›Paper›PMID 37685984›Full record

ArticleInternational journal of molecular sciences2023

Resveratrol and 2-Ethyl-6-Methyl-3-Hydroxypiridine N-Acetyl Cysteinate as Protecting Agents upon the Stress Exposure.

Irina V Zhigacheva, Irina F Rusina, Natalia I Krikunova, Aleksandr N Goloschapov, Timur L Veprintsev, Olga I Yablonskaya, Aleksei V Trofimov

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Irina V ZhigachevaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, Ul. Kosygina 4, Moscow 119334, Russia.ORCID 0000-0003-3790-1112
Irina F RusinaN.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Ul. Kosygina 4, Moscow 119334, Russia.
Natalia I KrikunovaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, Ul. Kosygina 4, Moscow 119334, Russia.
Aleksandr N GoloschapovEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, Ul. Kosygina 4, Moscow 119334, Russia.
Timur L VeprintsevEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, Ul. Kosygina 4, Moscow 119334, Russia.
Olga I YablonskayaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, Ul. Kosygina 4, Moscow 119334, Russia.
Aleksei V TrofimovEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, Ul. Kosygina 4, Moscow 119334, Russia.ORCID 0000-0003-2472-601X
Institute of Biochemical Physics NM Emanuel · RUMoscow Institute of Physics and Technology · RUSemenov Institute of Chemical Physics · RU

Funding

Ministry of Science and Higher Education, Russian Federation 001201253314/01201253310
6 · The paper itself

Abstract

The increased generation of reactive oxygen species (ROS) by mitochondria under stress conditions leads to lipid peroxidation (LPO) as a consequence of the ROS interactions with polyunsaturated fatty acids in the lipid bilayer of cell membranes, causing their damage. It was assumed that chemical preparations that reduce the excessive ROS generation by mitochondria should exhibit protecting properties under oxidative-stress conditions. In this context, the antioxidants resveratrol (RSV) and 2-ethyl-6-methyl-3-hydroxypyridine N-acetylcysteinate (NAC-3-HP) were examined as potential chemical protectors upon the exposure to stress, able to maintain the functional state of mitochondria.

Indexed as

AntioxidantsLipid BilayersCell MembraneReactive Oxygen SpeciesResveratrolAntioxidantsLipid BilayersReactive Oxygen SpeciesResveratrol2-ethyl-6-methyl-3-hydroxypiridine N-acetyl cysteinatebioantioxidantschemiluminescence assaymitochondriaoxidative stressresveratrolROS generation and scavenging

Identifiers

PMID37685984
PMCPMC10487494
OpenAlexW4386141812

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.