Evidence map›Paper›PMID 37685932›Full record

ArticleInternational journal of molecular sciences2023

Transcriptome from Paired Samples Improves the Power of Comprehensive COVID-19 Host-Viral Characterization.

Ognjen Milicevic, Ana Loncar, Dzihan Abazovic, Marija Vukcevic, Dragana Despot, Tatjana Djukic, Vladimir Djukic, Andjela Milovanovic, Nikola Panic, Nemanja Plecic and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ognjen MilicevicInstitute for Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0003-4394-4768
Ana LoncarInstitute for Biocides and Medical Ecology, 11000 Belgrade, Serbia.
Dzihan AbazovicBiocell Hospital, 11000 Belgrade, Serbia.
Marija VukcevicInstitute for Biocides and Medical Ecology, 11000 Belgrade, Serbia.ORCID 0000-0002-7540-0215
Dragana DespotInstitute for Biocides and Medical Ecology, 11000 Belgrade, Serbia.
Tatjana DjukicInstitute of Medical and Clinical Biochemistry, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0003-1959-5115
Vladimir DjukicFaculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Andjela MilovanovicFaculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Nikola PanicFaculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Nemanja PlecicUniversity Clinic "Dr Dragisa Misovic", 11000 Belgrade, Serbia.
Ana BankoInstitute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-6829-096X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous transcriptome profiling studies showed significantly upregulated genes and altered biological pathways in acute COVID-19. However, changes in the transcriptional signatures during a defined time frame are not yet examined and described. The aims of this study included viral metagenomics and evaluation of the total expression in time-matched and tissue-matched paired COVID-19 samples with the analysis of the host splicing profile to reveal potential therapeutic targets. Prospective analysis of paired nasopharyngeal swabs (NPS) and blood (BL) samples from 18 COVID-19 patients with acute and resolved infection performed using Kallisto, Suppa2, Centrifuge, EdgeR, PantherDB, and

Indexed as

COVID-19SARS-CoV-2Computational BiologyGene Expression ProfilingHumansTranscriptomeCOVID-19differential expression (DEG)metagenomicspairingRNASARS-CoV-2therapeuticstranscriptome

Identifiers

PMID37685932
PMCPMC10487753

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.